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2023 , Vol. 43 >Issue 6: 1991 - 2001

DOI: https://doi.org/10.6023/cjoc202211024

综述与进展

无保护糖基化反应研究进展

  • 李格非 ,
  • 荆杰 ,
  • 罗振扬 ,
  • 默娟 ,
  • 熊德彩 ,
  • 叶新山
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  • a 南京林业大学理学院 南京 210037
    b 北京大学药学院 天然药物及仿生药物国家重点实验室 北京 100191

收稿日期: 2022-11-22

  修回日期: 2022-12-26

  网络出版日期: 2023-01-12

基金资助

国家自然科学基金(21907004); 国家自然科学基金(81821004); 天然药物及仿生药物国家重点实验室开放基金(K202216)

收起

Recent Advances in Protection-Free Glycosylations

  • Gefei Li ,
  • Jie Jing ,
  • Zhenyang Luo ,
  • Juan Mo ,
  • Decai Xiong ,
  • Xinshan Ye
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  • a School of Science, Nanjing Forestry University, Nanjing 210037
    b State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191
* E-mail:

Received date: 2022-11-22

  Revised date: 2022-12-26

  Online published: 2023-01-12

Supported by

National Natural Science Foundation of China(21907004); National Natural Science Foundation of China(81821004); State Key Laboratory of Natural and Biomimetic Drugs(K202216)

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摘要

糖类在很多生命活动中发挥着重要的作用, 例如细胞壁组成、能量储存以及生物识别等. 发展高区域选择性和立体选择性的糖基化反应是目前糖化学研究的中心问题. 传统的化学糖基化方法往往需要依靠正交的保护基化学来调控糖基化反应的选择性. 近年来一些无保护糖基化的策略被开发出来, 可以在更简单、更温和的条件下实现寡糖及其缀合物的选择性合成. 对近期发展的无保护糖基化策略进行了综述, 并对无保护糖基化反应的未来发展前景进行展望.

关键词： 化学糖基化反应; 无保护; 直接端基活化; 糖化学

本文引用格式

李格非 , 荆杰 , 罗振扬 , 默娟 , 熊德彩 , 叶新山 . 无保护糖基化反应研究进展[J]. 有机化学, 2023 , 43(6) : 1991 -2001 . DOI: 10.6023/cjoc202211024

Abstract

Carbohydrates play a key role in many life activities, such as cell wall composition, energy storage and biological recognition. Development of highly regio- and stereo-selective glycosylation reactions is a central topic of current carbohydrate chemistry. The traditional glycosylation protocol usually requires the orthogonal protecting chemistry to obtain the selectivity of glycosylation reactions. Recent progress in protecting-group free strategies can provide a simple and mild approach to the chemo-selective construction of glycosidic bonds in oligosaccharides or glycoconjugates in aqueous conditions. The latest advances in protection-free chemical glycosylations are summarized, including the direct anomeric activation strategy developed by our group.

Key words： chemical glycosylation; protection-free; direct anomeric activation; carbohydrate chemistry

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