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2023 , Vol. 43 >Issue 6: 2104 - 2109

DOI: https://doi.org/10.6023/cjoc202212014

研究论文

电化学促进咪唑并[1,2-a]吡啶与二氯(溴)乙烷及碘仿的卤化反应

  • 张周 ,
  • 郭钰 ,
  • 羊静 ,
  • 吴丹 ,
  • 王佳昕 ,
  • 洪欣玥 ,
  • 蔡佩君 ,
  • 荣良策
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  • a 中国矿业大学化工学院 江苏徐州 221116
    b 江苏师范大学化学与材料科学学院 江苏徐州 221116

收稿日期: 2022-12-12

  修回日期: 2023-01-07

  网络出版日期: 2023-01-18

基金资助

江苏省高校自然科学研究(18KJA150004); 大学生创新创业训练计划和江苏省高校品牌专业资助项目

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Electrochemically Promoted Halogenation of Imidazoland-[1,2-a]pyridine with Dichloro(bromo)ethylene and Iodoform

  • Zhou Zhang ,
  • Yu Guo ,
  • Jing Yang ,
  • Dan Wu ,
  • Jiaxin Wang ,
  • Xinyue Hong ,
  • Peijun Cai ,
  • Liangce Rong
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  • a Department of Chemical Engineering &Technology, China University of Mining and Technology, Xuzhou, Jiangsu 221004
    b School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, Jiangsu 221116
* E-mail: ;

Received date: 2022-12-12

  Revised date: 2023-01-07

  Online published: 2023-01-18

Supported by

Natural Science Foundation of the Jiangsu Higher Education Institutions(18KJA150004); Undergraduate Innovation and Entrepreneurship Training Program and the Brand Major of Universities in Jiangsu Province

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摘要

报道了在电化学条件下2-芳基咪唑并[1,2-a]吡啶与二氯乙烷、二溴乙烷及碘仿发生卤化反应. 研究表明二氯(溴)乙烷和碘仿都是有效的卤源试剂. 本研究为3-卤代咪唑并[1,2-a]吡啶衍生物的合成提供了一条有效途径.

关键词： 电化学; 卤化; 咪唑并[1,2-a]吡啶; 二氯(溴)乙烷; 碘仿

本文引用格式

张周 , 郭钰 , 羊静 , 吴丹 , 王佳昕 , 洪欣玥 , 蔡佩君 , 荣良策 . 电化学促进咪唑并[1,2-a]吡啶与二氯(溴)乙烷及碘仿的卤化反应[J]. 有机化学, 2023 , 43(6) : 2104 -2109 . DOI: 10.6023/cjoc202212014

Abstract

An electrochemical halogenation of 2-arylimidazoland[1,2-a]pyridine with dichloro(bromo)ethylene and iodoform is reported. Studies show that dichloroethane, dibromoethane and iodoform are excellent halogen source reagents in this synthesis. The present protocol provides alternative route to obtain 3-halogenatedimidazo[1,2-a]pyridines derivatives.

Key words： electrochemistry; halogenation; imidazoland[1,2-a]pyridine; dichloro(bromo)ethylene; iodoform

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