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2023 , Vol. 43 >Issue 6: 1952 - 1962

DOI: https://doi.org/10.6023/cjoc202210030

综述与进展

线粒体靶向的二氧化硫荧光探针研究进展

  • 李宜芳 ,
  • 王耀 ,
  • 牛华伟 ,
  • 陈秀金 ,
  • 李兆周 ,
  • 王永国
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  • a 河南科技大学食品与生物工程学院/河南省食品绿色加工与质量安全控制国际联合实验室 河南洛阳 471000
    b 安阳学院 河南安阳 455000

收稿日期: 2022-10-24

  修回日期: 2023-01-21

  网络出版日期: 2023-02-15

基金资助

国家自然科学基金(31702218); 河南省青年人才托举工程(2020HYTP029); 河南省研究生教育改革与质量提升工程(HNYJS2020JD06); 河南省科技攻关(232102320298); 河南省科技攻关(222102310524)

收起

Research Progress of Sulfur Dioxide Fluorescent Probe Targeting Mitochondria

  • Yifang Li ,
  • Yao Wang ,
  • Huawei Niu ,
  • Xiujin Chen ,
  • Zhaozhou Li ,
  • Yongguo Wang
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  • a College of Food & Bioengineering, Henan University of Science and Technology/Henan International Joint Laboratory of Food Green Processing and Quality Safety Control, Luoyang, Henan 471000
    b Anyang University, Anyang, Henan 455000
* E-mail: ;

Received date: 2022-10-24

  Revised date: 2023-01-21

  Online published: 2023-02-15

Supported by

National Natural Science Foundation of China(31702218); Youth Talent Support Project of Henan Province(2020HYTP029); Postgraduate Education Reform and Quality Improvement Project of Henan Province(HNYJS2020JD06); Scientific and Technological Research Project of Henan Province(232102320298); Scientific and Technological Research Project of Henan Province(222102310524)

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摘要

二氧化硫(SO2)与生命系统中的许多生理和病理过程有关, 过量的SO2会导致一系列生理疾病. 因此, 有效地识别和检测SO2具有显著的应用价值. 近年来, 已经报道了许多用于检测生物体系中SO2的荧光探针. 与传统的检测方法相比, 荧光探针具有灵敏度高、无创检测及实时成像等优点, 更重要的是, 使用荧光探针可以在体外和体内对SO2进行可视化检测. 根据不同的反应机理, 综述了近五年线粒体靶向的SO2荧光探针的研究进展, 探讨了该领域面临的挑战和发展方向.

关键词： 线粒体; 荧光探针; 二氧化硫; 细胞成像

本文引用格式

李宜芳 , 王耀 , 牛华伟 , 陈秀金 , 李兆周 , 王永国 . 线粒体靶向的二氧化硫荧光探针研究进展[J]. 有机化学, 2023 , 43(6) : 1952 -1962 . DOI: 10.6023/cjoc202210030

Abstract

Content of abstract sulfur dioxide (SO2) is associated with many physiological and pathological processes in living systems, and excessive SO2 can lead to a series of physiological diseases. Therefore, effective identification and detection of SO2 have significant application value. Recently, many fluorescent probes for the detection of SO2 in biological systems have been reported. Compared with traditional detection methods, fluorescent probe has the advantages of high sensitivity, non-invasive detection and real-time imaging. More importantly, the use of fluorescent probes allows visual detection of SO2 both in vitro and in vivo. Based on different reaction mechanism, the research progress of mitochondrial targeted SO2 fluorescent probes in the past five years is reviewed, and the challenges and development directions in this field are discussed.

Key words： mitochondria; fluorescent probe; sulfur dioxide; cell imaging

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