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2023 , Vol. 43 >Issue 3: 1091 - 1101

DOI: https://doi.org/10.6023/cjoc202211028

研究论文

铜催化环状烯烃烯丙位C(sp3)—H磺酰化反应研究

  • 刘春阳 ,
  • 李燕 ,
  • 张前
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  • a 东北师范大学化学学院 长春 130024
    b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032

收稿日期: 2022-11-24

  修回日期: 2023-02-16

  网络出版日期: 2023-03-01

基金资助

国家自然科学基金(22193012); 国家自然科学基金(21831002); 中央高校基本科研业务经费(2412022ZD049)

收起

Copper-Catalyzed Allylic C(sp3)—H Sulfonylation of Cyclic Olefins

  • Chunyang Liu ,
  • Yan Li ,
  • Qian Zhang
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  • a Department of Chemistry, Northeast Normal University, Changchun 130024
    b State key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
* Corresponding authors. E-mail: ;

Received date: 2022-11-24

  Revised date: 2023-02-16

  Online published: 2023-03-01

Supported by

National Natural Science Foundation of China(22193012); National Natural Science Foundation of China(21831002); Fundamental Research Funds for the Central Universities(2412022ZD049)

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摘要

发展了一种温和的铜催化烯丙位C(sp3)—H直接高效磺酰化方法, 以简单环状烯烃和亚磺酸钠为反应原料, 以中等至良好的收率合成了一系列烯丙基砜衍生物. 机理研究表明, 该反应可能经历了自由基中间体.

关键词： 铜催化; 自由基; 烯丙位C(sp3)—H; 磺化反应; 烯丙基砜

本文引用格式

刘春阳 , 李燕 , 张前 . 铜催化环状烯烃烯丙位C(sp3)—H磺酰化反应研究[J]. 有机化学, 2023 , 43(3) : 1091 -1101 . DOI: 10.6023/cjoc202211028

Abstract

A highly efficient copper-catalyzed direct sulfonylation of allylic C(sp3)—H bond was developed using simple cyclic olefins and sodium sulfite as starting materials. A series of allylic sulfone derivatives were synthesized in moderate to good yields under mild conditions. The mechanism study shows that the reaction might involve radical intermediates.

Key words： copper-catalyzed; radicals; allylic C(sp3)—H; sulfonation reaction; allylic sulfone

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