低共熔溶剂1,3-二甲基脲/L-(+)-酒石酸中(E)-2-苯乙烯基喹啉-3-羧酸类衍生物的绿色合成
收稿日期: 2023-01-16
修回日期: 2023-04-19
网络出版日期: 2023-05-11
基金资助
国家自然科学基金(21402011); 辽宁省博士启动基金(2019-BS-004); 辽宁省教育厅科学研究基金(LQ2019006)
Deep Eutectic Solvent of 1,3-Dimethylurea/L-(+)-Tartaric Acid for the Green Synthesis of (E)-2-Styrylquinoline-3-carboxylic Acid Derivatives
Received date: 2023-01-16
Revised date: 2023-04-19
Online published: 2023-05-11
Supported by
National Natural Science Foundation of China(21402011); Doctoral Start-Up Foundation of Liaoning Province(2019-BS-004); Scientific Research Foundation of the Education Department of Liaoning Province(LQ2019006)
李阳 , 袁锦鼎 , 赵頔 . 低共熔溶剂1,3-二甲基脲/L-(+)-酒石酸中(E)-2-苯乙烯基喹啉-3-羧酸类衍生物的绿色合成[J]. 有机化学, 2023 , 43(9) : 3268 -3276 . DOI: 10.6023/cjoc202301015
A green, efficient and catalyst-free synthesis of (E)-2-styrylquinoline-3-carboxylic acid derivatives via direct olefination of 2-methylquinoline-3-carboxylic acid with aromatic aldehydes has been accomplished successfully by using environmentally benign and non-toxic deep eutectic solvent (DES) of 1,3-dimethylurea (DMU)/L-(+)-tartaric acid (LTA) (n∶n=7∶3) as a dual catalyst and reaction medium. The synthetic strategy has the attractive features such as mild and environmentally benign reaction conditions, experimental simplicity, easy work-up procedure and good yields, which would contribute to the usefulness of this method.
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