有机化学 ›› 2023, Vol. 43 ›› Issue (9): 3268-3276.DOI: 10.6023/cjoc202301015 上一篇    下一篇

研究论文

低共熔溶剂1,3-二甲基脲/L-(+)-酒石酸中(E)-2-苯乙烯基喹啉-3-羧酸类衍生物的绿色合成

李阳*(), 袁锦鼎, 赵頔   

  1. 渤海大学化学与材料工程学院 辽宁锦州 121000
  • 收稿日期:2023-01-16 修回日期:2023-04-19 发布日期:2023-05-11
  • 基金资助:
    国家自然科学基金(21402011); 辽宁省博士启动基金(2019-BS-004); 辽宁省教育厅科学研究基金(LQ2019006)

Deep Eutectic Solvent of 1,3-Dimethylurea/L-(+)-Tartaric Acid for the Green Synthesis of (E)-2-Styrylquinoline-3-carboxylic Acid Derivatives

Yang Li(), Jinding Yuan, Di Zhao   

  1. College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, Liaoning 121000
  • Received:2023-01-16 Revised:2023-04-19 Published:2023-05-11
  • Contact: E-mail: bhuzh@163.com
  • Supported by:
    National Natural Science Foundation of China(21402011); Doctoral Start-Up Foundation of Liaoning Province(2019-BS-004); Scientific Research Foundation of the Education Department of Liaoning Province(LQ2019006)

利用环境友好且无毒无害的1,3-二甲基脲(DMU)/L-(+)-酒石酸(LTA) (nn=7∶3)形成的低共熔溶剂(DES)作为反应介质和催化剂使2-甲基喹啉-3-羧酸与芳醛直接进行有效的乙烯化反应, 成功实现了(E)-2-苯乙烯基喹啉-3-羧酸类衍生物的绿色合成. 所开发的合成方法具有温和且环境友好的反应条件, 实验操作简便, 后处理简单和收率高等优点, 具有很好的实际应用价值.

关键词: 绿色合成, 2-苯乙烯基喹啉, 1,3-二甲基脲, L-(+)-酒石酸, 低共熔溶剂

A green, efficient and catalyst-free synthesis of (E)-2-styrylquinoline-3-carboxylic acid derivatives via direct olefination of 2-methylquinoline-3-carboxylic acid with aromatic aldehydes has been accomplished successfully by using environmentally benign and non-toxic deep eutectic solvent (DES) of 1,3-dimethylurea (DMU)/L-(+)-tartaric acid (LTA) (nn=7∶3) as a dual catalyst and reaction medium. The synthetic strategy has the attractive features such as mild and environmentally benign reaction conditions, experimental simplicity, easy work-up procedure and good yields, which would contribute to the usefulness of this method.

Key words: green synthesis, 2-styrylquinoline, 1,3-dimethylurea, L-(+)-tartaric acid, deep eutectic solvent