水-聚乙二醇(PEG-200)中烯烃与碘代芳烃绿色可循环无负载偶联反应的研究
收稿日期: 2023-02-28
修回日期: 2023-05-08
网络出版日期: 2023-05-30
基金资助
湖南省自然科学基金(2021JJ30537); 湖南省大学生创新训练基金(S202110548054); 国家自然科学基金(21563015)
A Green, Recyclable and Carrier-Free Study for the Coupling Reaction of Alkenes with Aryl Iodides in H2O-Polyethylene Glycol (PEG-200)
Received date: 2023-02-28
Revised date: 2023-05-08
Online published: 2023-05-30
Supported by
Natural Science Foundation of Hunan Province(2021JJ30537); University Students Innovation Training Foundation of Hunan Province(S202110548054); National Natural Science Foundation of China(21563015)
以环境友好的水-聚乙二醇(PEG-200)为反应介质, 发展了一种绿色、可循环Pd(OAc)2催化烯烃与碘代芳烃交叉偶联反应的新方法. 通过该方法可以获得一系列具有良好选择性和高收率的偶联产物. Pd(OAc)2-H2O-PEG-200体系可以直接回收并用于3次以上的循环而不失去反应活性, 证明整个无负载钯催化体系的稳定性. 该方法降低了反应成本, 操作简单, 有利于工业化生产.
关键词： 无负载; 可循环; 水-聚乙二醇(PEG-200); 交叉偶联; 绿色化学
蒋宜欣 , 唐伯孝 , 毛海波 , 陈雪霞 , 俞洋杰 , 全翠英 , 徐昭阳 , 石金慧 , 刘益林 . 水-聚乙二醇(PEG-200)中烯烃与碘代芳烃绿色可循环无负载偶联反应的研究[J]. 有机化学, 2023 , 43(9) : 3210 -3215 . DOI: 10.6023/cjoc202302030
By using an environmentally friendly H2O-polyethylene glycol (PEG-200) system as the reaction medium, a new, green and recyclable protocol was developed for Pd(OAc)2-catalyzed the cross-coupling reaction of alkenes with aryl iodides. A series of coupling products can be obtained with good selectivity and yield. The Pd(OAc)2-H2O-PEG-200 system can be directly recovered and used for more than three cycles without any loss of activity, demonstrating the robustness of the carrier-free palladium catalyst system. As the reaction cost is reduced and the operation is simple, the approach is beneficial to industrial production.
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