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2024 , Vol. 44 >Issue 1: 291 - 300

DOI: https://doi.org/10.6023/cjoc202306002

研究论文

铑(III)催化苯甲亚胺酸乙酯和CF3-亚胺氧锍叶立德C—H 活化/环化反应合成CF3-1H-苯并[de][1,8]萘吡啶

  • 文思 ,
  • 丁宇浩 ,
  • 田青于 ,
  • 葛进 ,
  • 程国林
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  • a 安康学院化学化工学院 陕西安康 725000
    b 华侨大学材料科学与工程学院 厦门市光电材料及其先进制造重点实验室 福建厦门 361021

收稿日期: 2023-06-01

  修回日期: 2023-07-26

  网络出版日期: 2023-08-22

基金资助

国家自然科学基金(22071068); 及华侨大学分析测试中心资助项目.

收起

Rhodium(III)-Catalyzed Synthesis of CF3-1H-benzo[de][1,8]naph-thyridines via C—H Activation/Annulation of Benzimidates and CF3-Imidoyl Sulfoxonium Ylides

  • Si Wen ,
  • Yuhao Ding ,
  • Qingyu Tian ,
  • Jin Ge ,
  • Guolin Cheng
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  • a College of Chemistry and Chemical Engineering, Ankang University, Ankang, Shaanxi 725000
    b Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing, College of Materials Science and Engineering, Huaqiao University, Xiamen, Fujian 361021
*E-mail:

Received date: 2023-06-01

  Revised date: 2023-07-26

  Online published: 2023-08-22

Supported by

National Natural Science Foundation of China(22071068); Instrumental Analysis Center of Huaqiao University.

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摘要

在铑催化下, 实现了苯甲亚胺酸乙酯类化合物与CF3-亚胺叶立德的C—H活化/环化多米诺反应. 该合成策略具有良好的官能团耐受性和底物的普适性, 合成了一系列含三氟甲基的1H-苯并[de][1,8]萘吡啶, 产率为22%~86%.

关键词： 铑催化; 苯甲胺酸乙酯; 三氟甲基; 氧锍叶立德; 苯并[de][1,8]萘吡啶

本文引用格式

文思 , 丁宇浩 , 田青于 , 葛进 , 程国林 . 铑(III)催化苯甲亚胺酸乙酯和CF3-亚胺氧锍叶立德C—H 活化/环化反应合成CF3-1H-苯并[de][1,8]萘吡啶[J]. 有机化学, 2024 , 44(1) : 291 -300 . DOI: 10.6023/cjoc202306002

Abstract

A rhodium-catalyzed C—H activation/annulation domino reaction of benzimidates and CF3-imidoyl sulfoxonium ylides has been achieved. This synthetic strategy has good functional groups tolerance and universality of substrates, and a series of trifluoromethyl-containing 1H-benzo[de][1,8]naphthyridines were synthesized in 22%~86% yields.

Key words： rhodium catalysis; benzimidate; trifluoromethyl; sulfoxonium ylide; benzo[de][1,8]naphthyridine

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