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2024 , Vol. 44 >Issue 1: 282 - 290

DOI: https://doi.org/10.6023/cjoc202306004

研究论文

手性P,N,N-配体/钯催化的不对称烯丙基取代反应

  • 秦浩 ,
  • 侯传金 ,
  • 梁丁化 ,
  • 何心伟 ,
  • 李玲 ,
  • 胡向平
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  • a 大连工业大学轻工与化学工程学院 辽宁大连 116034
    b 安徽师范大学功能分子固体教育部重点实验室 安徽芜湖 241000
    c 中国科学院大连化学物理研究所 辽宁大连 116023

收稿日期: 2023-06-05

  修回日期: 2023-07-23

  网络出版日期: 2023-08-22

基金资助

辽宁省自然科学基金(2022-MS-345); 功能分子固体教育部重点实验室(FMS201906)

收起

Chiral P,N,N-Ligands for Pd-Catalyzed Asymmetric Allylic Substitutions

  • Hao Qin ,
  • Chuanjin Hou ,
  • Dinghua Liang ,
  • Xinwei He ,
  • Ling Li ,
  • Xiangping Hu
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  • a School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian, Liaoning 116034
    b Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Normal University, Wuhu, Anhui 241000
    c Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023
*E-mail: ;
E-mail: ;
E-mail:

Received date: 2023-06-05

  Revised date: 2023-07-23

  Online published: 2023-08-22

Supported by

Natural Science Foundation of Liaoning Province(2022-MS-345); Key Laboratory of Functional Molecular Solids, Ministry of Education(FMS201906)

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摘要

P,N,N-配体是近年来发展起来的在不对称催化反应中具有广泛应用的一类手性配体. 将手性P,N,N-配体应用于钯催化不对称烯丙基取代反应研究. 结果表明, 在较温和条件下, 含C、N和O的各类亲核试剂均能顺利发生反应, 获得良好的产率和对映选择性(产率高达97%, 93% ee).

关键词： P,N,N-配体; 不对称烯丙基取代; 钯

本文引用格式

秦浩 , 侯传金 , 梁丁化 , 何心伟 , 李玲 , 胡向平 . 手性P,N,N-配体/钯催化的不对称烯丙基取代反应[J]. 有机化学, 2024 , 44(1) : 282 -290 . DOI: 10.6023/cjoc202306004

Abstract

Chiral P,N,N-ligands are a new type of ligands developed in recent years, which have been widely used in asymmetric catalytic reactions. In this study, chiral P,N,N-ligands were applied to palladium-catalyzed asymmetric allylic substitution reactions. The results showed that under mild conditions, various nucleophiles containing carbon, nitrogen and oxygen could react smoothly, achieving good yields (up to 97% yield) and enantioselectivities (up to 93% ee).

Key words： P,N,N-ligands; asymmetric allylic substitution; palladium

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