有机化学 ›› 2024, Vol. 44 ›› Issue (1): 282-290.DOI: 10.6023/cjoc202306004 上一篇    下一篇

研究论文

手性P,N,N-配体/钯催化的不对称烯丙基取代反应

秦浩a, 侯传金a,b,*(), 梁丁化a, 何心伟b, 李玲a,c,*(), 胡向平c,*()   

  1. a 大连工业大学轻工与化学工程学院 辽宁大连 116034
    b 安徽师范大学功能分子固体教育部重点实验室 安徽芜湖 241000
    c 中国科学院大连化学物理研究所 辽宁大连 116023
  • 收稿日期:2023-06-05 修回日期:2023-07-23 发布日期:2023-08-22
  • 基金资助:
    辽宁省自然科学基金(2022-MS-345); 功能分子固体教育部重点实验室(FMS201906)

Chiral P,N,N-Ligands for Pd-Catalyzed Asymmetric Allylic Substitutions

Hao Qina, Chuanjin Houa,b(), Dinghua Lianga, Xinwei Heb, Ling Lia,c(), Xiangping Huc()   

  1. a School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian, Liaoning 116034
    b Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Normal University, Wuhu, Anhui 241000
    c Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023
  • Received:2023-06-05 Revised:2023-07-23 Published:2023-08-22
  • Contact: *E-mail: houcj@dlpu.edu.cn; E-mail: 18840836643@163.com; E-mail: xiangping@dicp.ac.cn
  • Supported by:
    Natural Science Foundation of Liaoning Province(2022-MS-345); Key Laboratory of Functional Molecular Solids, Ministry of Education(FMS201906)

P,N,N-配体是近年来发展起来的在不对称催化反应中具有广泛应用的一类手性配体. 将手性P,N,N-配体应用于钯催化不对称烯丙基取代反应研究. 结果表明, 在较温和条件下, 含C、N和O的各类亲核试剂均能顺利发生反应, 获得良好的产率和对映选择性(产率高达97%, 93% ee).

关键词: P,N,N-配体, 不对称烯丙基取代,

Chiral P,N,N-ligands are a new type of ligands developed in recent years, which have been widely used in asymmetric catalytic reactions. In this study, chiral P,N,N-ligands were applied to palladium-catalyzed asymmetric allylic substitution reactions. The results showed that under mild conditions, various nucleophiles containing carbon, nitrogen and oxygen could react smoothly, achieving good yields (up to 97% yield) and enantioselectivities (up to 93% ee).

Key words: P,N,N-ligands, asymmetric allylic substitution, palladium