本文发展了一种高效的吲哚酮的C-3位直接硫化反应。通过使用二硫化物作为硫化试剂,t-BuOK/DMF作为催化剂,一系列吲哚酮的C-3位硫化产物被成功合成。该方法具有较高的原子经济性、环境友好且底物适应范围广。
王丽丽
,
张洲
,
王廷良
,
王兴兰
,
毛远湖
,
张吉泉
. t-BuOK/DMF促进的通过自由基过程实现吲哚酮的C-3位硫化反应[J]. 有机化学, 0
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DOI: 10.6023/cjoc202312024
An efficient C-3 sulfuration of oxindoles has been developed. Using disulfide as the sulfurating agent, a wide range of sulfurated oxindoles have been synthesized under t-BuOK/DMF promoted conditions. The present method was highly atom economic, environmentally friendly and tolerated a broad scope of substrates.
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