t-BuOK/DMF促进的通过自由基过程实现吲哚酮的C-3位硫化反应

doi:10.6023/cjoc202312024

有机化学

t-BuOK/DMF促进的通过自由基过程实现吲哚酮的C-3位硫化反应

王丽丽, 张洲, 王廷良, 王兴兰, 毛远湖, 张吉泉^*

贵州医科大学贵州省化学合成药物研发利用工程技术研究中心,贵州医科大学药学院,贵阳,561113

收稿日期:2024-03-11 修回日期:2024-04-18

t-BuOK/DMF-promoted C-3 sulfuration of oxindoles via a radical process

Wang Lili, Zhang Zhou, Wang Tingliang, Wang Xinglan, Mao Yuanhu, Zhang Jiquan^*

Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, College of Pharmacy, Guizhou Medical University, Guiyang, 561113, China

Received:2024-03-11 Revised:2024-04-18
Contact: ^*E-mail: zjqgmc@163.com

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摘要/Abstract

本文发展了一种高效的吲哚酮的C-3位直接硫化反应。通过使用二硫化物作为硫化试剂,t-BuOK/DMF作为催化剂,一系列吲哚酮的C-3位硫化产物被成功合成。该方法具有较高的原子经济性、环境友好且底物适应范围广。

关键词: 吲哚酮, 二硫化物, 硫化反应, 自由基

An efficient C-3 sulfuration of oxindoles has been developed. Using disulfide as the sulfurating agent, a wide range of sulfurated oxindoles have been synthesized under t-BuOK/DMF promoted conditions. The present method was highly atom economic, environmentally friendly and tolerated a broad scope of substrates.

Key words: Oxindole, disulfide, sulfuration, radical

引用此文

王丽丽, 张洲, 王廷良, 王兴兰, 毛远湖, 张吉泉. t-BuOK/DMF促进的通过自由基过程实现吲哚酮的C-3位硫化反应[J]. 有机化学, doi: 10.6023/cjoc202312024.

Wang Lili, Zhang Zhou, Wang Tingliang, Wang Xinglan, Mao Yuanhu, Zhang Jiquan. t-BuOK/DMF-promoted C-3 sulfuration of oxindoles via a radical process[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202312024.

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