聚集诱导发光材料用于肿瘤光学诊疗

黄伟庚; 高翼亭; 孙妍; 燕鼎元; 王东; 唐本忠

doi:10.6023/cjoc202403059

有机化学 >

2024 , Vol. 44 >Issue 8: 2413 - 2424

DOI: https://doi.org/10.6023/cjoc202403059

综述与进展

聚集诱导发光材料用于肿瘤光学诊疗

黄伟庚 ,
高翼亭 ,
孙妍 ,
燕鼎元 ,
王东 ,
唐本忠

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a 深圳大学材料学院聚集诱导发光(AIE)研究中心广东深圳 518060
b 东北师范大学化学学院吉林省高校纳米生物传感与纳米生物分析重点实验室长春 130024
c 香港中文大学(深圳)理工学院深圳分子聚集体科学与工程研究院广东深圳 518172

† 共同第一作者.

收稿日期: 2024-03-31

修回日期: 2024-06-19

网络出版日期: 2024-07-02

基金资助

国家自然科学基金(52122317); 国家自然科学基金(22175120); 国家自然科学基金(22307080); 深圳市科技发展基金(RCBS20221008093224016); 深圳市科技发展基金(JCYJ20220531101201003); 深圳市科技发展基金(JCYJ20190808153415062); 深圳市科技发展基金(20220809130438001); 深圳市科技发展基金(JSGG20220606141800001); 深圳市科技发展基金(JCYJ20200109110608167); 及广东省基础与应用基础研究基金(2023A1515010558)

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Aggregation-Induced Emission Materials for Tumor Phototheranostics

Weigeng Huang ,
Yiting Gao ,
Yan Sun ,
Dingyuan Yan ,
Dong Wang ,
BenZhong Tang

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a Center for Aggregation-Induced Emission (AIE) Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong 518060
b Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024
c School of Science and Engineering, Shenzhen Institute of Molecular Aggregate Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172

† These authors contributed equally to this work.

*E-mail: yandingyuan@szu.edu.cn;

wangd@szu.edu.cn;

tangbenz@cuhk.edu.cn

Received date: 2024-03-31

Revised date: 2024-06-19

Online published: 2024-07-02

Supported by

National Natural Science Foundation of China(52122317); National Natural Science Foundation of China(22175120); National Natural Science Foundation of China(22307080); Developmental Fund for Science and Technology of Shenzhen Government(RCBS20221008093224016); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20220531101201003); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20190808153415062); Developmental Fund for Science and Technology of Shenzhen Government(20220809130438001); Developmental Fund for Science and Technology of Shenzhen Government(JSGG20220606141800001); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20200109110608167); Guangdong Basic and Applied Basic Research Fund(2023A1515010558)

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摘要

近年来, 聚集诱导发光(AIE)材料因其优异的聚集态增强诊疗特性在肿瘤诊疗领域备受关注. 激发后的AIE材料可以通过不同的能量弛豫途径耗散激发态能量, 产生活性氧或光热, 用于成像导航下的肿瘤一体化诊疗. 根据激发方式的不同, 系统地总结了AIE材料用于肿瘤诊疗的研究进展, 具体包括光致激发(包含使用白光、660、808、980或1064 nm激光器)、化学激发、超声激发和X射线激发. 此外, 简要讨论了每种激发方式的优势和局限性.

关键词： 聚集诱导发光; 激发源; 肿瘤诊疗

本文引用格式

黄伟庚 , 高翼亭 , 孙妍 , 燕鼎元 , 王东 , 唐本忠 . 聚集诱导发光材料用于肿瘤光学诊疗[J]. 有机化学, 2024 , 44(8) : 2413 -2424 . DOI: 10.6023/cjoc202403059

Abstract

In recent years, aggregation-induced emission (AIE) materials have attracted much attention in the field of tumour treatment due to their excellent attributes of aggregation-enhanced theranostics. The AIE materials can dissipate the excited state energy through different energy relaxation pathways to generate reactive oxygen species or heat, which can be used for imaging-guided tumour phototherapy. The research progress of AIE materials for tumor phototheranostics is systematically summarized according to the different excitation modes, specifically photogenic excitation (including the use of white light, 660, 808, 980 or 1064 nm lasers), chemical excitation, ultrasonic excitation and X-ray excitation. In addition, the advantages and limitations of each excitation energy source are briefly discussed.

Key words： aggregation-induced emission; excitation source; tumor theranostics

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