聚集诱导发光材料用于肿瘤光学诊疗

doi:10.6023/cjoc202403059

有机化学 ›› 2024, Vol. 44 ›› Issue (8): 2413-2424.DOI: 10.6023/cjoc202403059 上一篇下一篇

综述与进展

聚集诱导发光材料用于肿瘤光学诊疗

黄伟庚^a, 高翼亭^a^,^b, 孙妍^a^,^b, 燕鼎元^a^,^*(), 王东^a^,^*(), 唐本忠^a^,^c^,^*()

a 深圳大学材料学院聚集诱导发光(AIE)研究中心广东深圳 518060
b 东北师范大学化学学院吉林省高校纳米生物传感与纳米生物分析重点实验室长春 130024
c 香港中文大学(深圳)理工学院深圳分子聚集体科学与工程研究院广东深圳 518172

收稿日期:2024-03-31 修回日期:2024-06-19 发布日期:2024-07-02
作者简介:
† 共同第一作者.
基金资助:
国家自然科学基金(52122317); 国家自然科学基金(22175120); 国家自然科学基金(22307080); 深圳市科技发展基金(RCBS20221008093224016); 深圳市科技发展基金(JCYJ20220531101201003); 深圳市科技发展基金(JCYJ20190808153415062); 深圳市科技发展基金(20220809130438001); 深圳市科技发展基金(JSGG20220606141800001); 深圳市科技发展基金(JCYJ20200109110608167); 及广东省基础与应用基础研究基金(2023A1515010558)

Aggregation-Induced Emission Materials for Tumor Phototheranostics

Weigeng Huang^a, Yiting Gao^a^,^b, Yan Sun^a^,^b, Dingyuan Yan^a(), Dong Wang^a(), BenZhong Tang^a^,^c()

a Center for Aggregation-Induced Emission (AIE) Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong 518060
b Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024
c School of Science and Engineering, Shenzhen Institute of Molecular Aggregate Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172

Received:2024-03-31 Revised:2024-06-19 Published:2024-07-02
Contact: *E-mail: yandingyuan@szu.edu.cn; wangd@szu.edu.cn; tangbenz@cuhk.edu.cn
About author:
† These authors contributed equally to this work.
Supported by:
National Natural Science Foundation of China(52122317); National Natural Science Foundation of China(22175120); National Natural Science Foundation of China(22307080); Developmental Fund for Science and Technology of Shenzhen Government(RCBS20221008093224016); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20220531101201003); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20190808153415062); Developmental Fund for Science and Technology of Shenzhen Government(20220809130438001); Developmental Fund for Science and Technology of Shenzhen Government(JSGG20220606141800001); Developmental Fund for Science and Technology of Shenzhen Government(JCYJ20200109110608167); Guangdong Basic and Applied Basic Research Fund(2023A1515010558)

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摘要/Abstract

近年来, 聚集诱导发光(AIE)材料因其优异的聚集态增强诊疗特性在肿瘤诊疗领域备受关注. 激发后的AIE材料可以通过不同的能量弛豫途径耗散激发态能量, 产生活性氧或光热, 用于成像导航下的肿瘤一体化诊疗. 根据激发方式的不同, 系统地总结了AIE材料用于肿瘤诊疗的研究进展, 具体包括光致激发(包含使用白光、660、808、980或1064 nm激光器)、化学激发、超声激发和X射线激发. 此外, 简要讨论了每种激发方式的优势和局限性.

关键词: 聚集诱导发光, 激发源, 肿瘤诊疗

In recent years, aggregation-induced emission (AIE) materials have attracted much attention in the field of tumour treatment due to their excellent attributes of aggregation-enhanced theranostics. The AIE materials can dissipate the excited state energy through different energy relaxation pathways to generate reactive oxygen species or heat, which can be used for imaging-guided tumour phototherapy. The research progress of AIE materials for tumor phototheranostics is systematically summarized according to the different excitation modes, specifically photogenic excitation (including the use of white light, 660, 808, 980 or 1064 nm lasers), chemical excitation, ultrasonic excitation and X-ray excitation. In addition, the advantages and limitations of each excitation energy source are briefly discussed.

Key words: aggregation-induced emission, excitation source, tumor theranostics

引用此文

黄伟庚, 高翼亭, 孙妍, 燕鼎元, 王东, 唐本忠. 聚集诱导发光材料用于肿瘤光学诊疗[J]. 有机化学, 2024, 44(8): 2413-2424.

Weigeng Huang, Yiting Gao, Yan Sun, Dingyuan Yan, Dong Wang, BenZhong Tang. Aggregation-Induced Emission Materials for Tumor Phototheranostics[J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2413-2424.

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图/表 9

图1. (A) AIE[以六苯基噻咯(HPS)为代表]和ACQ(苝为代表)现象对比图、(B)不同生物成像窗口穿透深度示意图及(C) AIE材料在不同激发方式下用于肿瘤的一体化诊疗

Figure 1. (A) Phenomena of aggregation-induced emission (taking HPS as example) and aggregation-caused quenching (taking perylene as example), (B) schematic of the penetration depth of different bio-imaging windows, and (C) AIE materials under different excitation modalities for integrated tumor diagnosis and treatment

图2. (A) MeTTPy的分子特性、(B) MeTTPy用于正常细胞和癌细胞染色区分(FLI)、(C)瘤内注射MeTTPy后A431荷瘤小鼠体内荧光成像图、(D)光照射下TPA-DHPy-Py的光氧化脱氢结构变化、(E) TPA-DHPy-Py在细胞内产生ROS的共聚焦成像图、(F)光激活TPA-DHPy-Py用于裸鼠肿瘤荧光成像、(G) TBFT2分子设计、光物理过程以及荧光导航下的PDT/PTT联合肿瘤诊疗示意图、(H) TBFT2 NPs的细胞共定位成像、(I) TBFT2 NPs在4T1细胞内产生ROS的效果考察及(J)注射TBFT2 NPs后不同时间节点的4T1荷瘤小鼠荧光成像图

Figure 2. (A) Properties of MeTTPy, (B) FLI of normal and cancer cells stained with MeTTPy, (C) fluorescence images of MeTTPy in A431 loaded mice at different times after intratumor injection, (D) photo-oxidative dehydrogenation of TPA-DHPy-Py under light irradiation, (E) ROS generation efficiency of TPA-DHPy-Py in living cells; (F) FLI of nude mice injected intratumourally with TPA-DHPy-Py, (G) molecular design strategy and photophysical processes of TBFT2 and its application in FLI-guided tumor combined PDT/PTT, (H) cellular co-localization study of TBFT2 NPs; (I) ROS generation calculation of TBFT2 NPs in 4T1 cells, and (J) time-dependent FLI of 4T1 tumor-bearing mice after injection of TBFT2 NPs

图3. (A)通过BTPPA的聚集态转变提高光热转化示意图、(B)尾静脉分别注射PAE NPs和PEG NPs后, 4T1荷瘤小鼠光热成像图、(C) π-桥工程策略构建多模态AIE材料示意图、(D) BT-NS NPs在4T1细胞内ROS生成荧光图及(E)在注射BT-NS NPs后不同时间点的肿瘤NIR-II FLI和PAI

Figure 3. (A) Schematic diagram of improved photothermal conversion by aggregation transition of BTPPA, (B) IR thermal images of 4T1 tumor-bearing mice after intravenous injection of PAE NPs and PEG NPs, (C) π-bridge engineering for the construction of multi-mode AIE materials, (D) fluorescence images of intracellular ROS in 4T1 cells after injection of BT-NS NPs, and (E) NIR-II FLI and PAI of tumors at different time points after injection of BT-NS NPs

图4. (A) ZSY-TPE分子的设计和应用示意图、(B) DHTDP NP@M仿生纳米材料的设计理念和制备过程示意图、不同小鼠肿瘤在注射DHTDP-NP和DHTDP-NP@M后的(C) NIR-II FLI图和(D) PTI图、(E) DPBTA-DPTQ分子的设计理念和激发后的光物理过程示意图及静脉注射DPBTA-DPTQ NPs后HepG2荷瘤小鼠在不同时间点的(F) NIR-II FLI图和(G) PAI图

Figure 4. (A) Design and biomedical application of ZSY-TPE, (B) design philosophy and preparation processes of DHTDP NP@M biomimetic nanoparticles, (C) NIR-II FLI and (D) PTI of mice tumors after intravenous injection of DHTDP-NP and DHTDP-NP@M, (E) design principle of DPBTA-DPTQ and the schematic diagram of its photophysical process after photoexcitation, and (F) NIR-II FLI and (G) PAI of HepG2 tumor-bearing mice after intravenous injection of DPBTA-DPTQ NPs at different monitoring times

图5. (A) BK@AIE NPs制备示意图、(B)尾静脉注射BK@AIE NPs后小鼠脑部的PTI图、(C)一种980 nm激发的AIE上转换UCNP@TTD-cRGD纳米粒子制备示意图及(D)尾静脉注射UCNP@TTD-cRGD NPs后荷瘤小鼠的FLI图

Figure 5. (A) Fabrication process of BK@AIE NPs, (B) PTI images of mice brain after intravenous injection of BK@AIE NPs, (C) schematic of the design of a 980-nm excitable upconversion therapeutic nanoplatform UCNP@TTD-cRGD NPs based on AIE-emitting molecules, (D) FLI images of tumor-bearing mice after intravenous injection of UCNP@TTD-cRGD NPs

图6. (A) BETT-2 NPs的制备过程及其在小鼠原位乳腺癌的多模态光疗中的应用示意图、静脉注射BETT-2 NPs后原位乳腺荷瘤小鼠的(B) NIR-II FLI图和(C) PAI图、(D)注射BETT-2 NPs 12 h后, 小鼠肿瘤在连续1064 nm激光照射下的PTI图、(E)具有NIR-II峰值吸收的TPABT-TD NPs用于NIR-II肿瘤光学诊疗示意图、(F)不同厚度鸡胸肉下TPABT-TD NPs和ICG光热升温对比图及(G) TPABT-TD NPs在不同厚度鸡胸肉下的荧光成像图

Figure 6. (A) Preparation process of BETT-2 NPs and its application in multimodal phototherapy to combat breast cancer, (B) NIR-II FLI and (C) PTI images of 4T1 tumor-bearing mice after intravenous administration of BETT-2 NPs, (D) PTI images 12 h post-injection of BETT-2 NPs and continuously irradiated by 1064 nm laser, (E) schematic diagram of NIR-II absorbing nanoparticles for tumor eradication in the NIR-II region, (F) relative temperature elevations of TPABT-TD NPs and ICG after penetrating chicken breast tissue of designed thicknesses, and (G) fluorescence images of TPABT-TD NPs with designed thickness of chicken tissues on top of the samples

图7. (A)用于肿瘤高信噪比成像的“双锁”响应QM-B-CF CL探针、(B)小鼠体内的FL和CL成像对比图、(C) TBL纳米粒子制备示意图及其CL过程示意图和(D) TBL纳米粒子在不同时间节点下用于肿瘤中1O2监测CL成像图

Figure 7. (A) QM-B-CF for high signal-to-background imaging of tumors based on a sequential dual-lock CL strategy, (B) comparison FL and CL imaging of tumor-bearing mice, (C) schematic diagram of the preparation of TBL dots and the CL process, and (D) In vivo CL images of tumor-bearing mice after subcutaneous injection of TBL dots and 1O2

图8. (A) DPA-TPE-SCP NPs的制备、(B) DPA-TPE-SCP NPs在4T1细胞中经超声产生ROS的共聚焦成像图、(C) PAHN-1的制备过程示意图及(D)不同处理组的肿瘤肺转移对比

Figure 8. (A) Preparation process of DPA-TPE-SCP NPs, (B) Fluorescence images of intracellular ROS in 4T1 cells treated by DPA-TPE-SCP NPs and ultrasound, (C) fabrication of PAHN-1, and (D) comparison of tumour lung metastases in different treatment groups

图9. (A)纯有机TBDCR NPs在X射线照射下生成ROS示意图及(B) TBDCR NPs用于X-PDT

Figure 9. (A) Schematic of ROS generation from pure organic TBDCR NPs under X-ray irradiation and (B) TBDCR NPs for X-PDT

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聚集诱导发光材料用于肿瘤光学诊疗

Aggregation-Induced Emission Materials for Tumor Phototheranostics

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