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2025 , Vol. 45 >Issue 1: 168 - 188

DOI: https://doi.org/10.6023/cjoc202404040

综述与进展

过渡金属催化氮原子α位Csp3—H键官能团化反应研究进展

  • 张腾飞 ,
  • 常喆 ,
  • 陈春霞 ,
  • 彭进松
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  • a 东北林业大学化学化工与资源利用学院 哈尔滨 150040
    b 东北林业大学 黑龙江省合成化学与资源利用创新研究中心(国际合作) 哈尔滨 150040

收稿日期: 2004-04-04

  修回日期: 2024-07-17

  网络出版日期: 2024-07-25

基金资助

中央高校基本科研业务费(2572023CT12); 黑龙江省自然科学基金(LH2022B003); 国家自然科学基金(32370413); 碳中和专项科学基金(HKF221700013)

收起

Progress in Functionalization of N-α-Csp3—H Bond Catalyzed by Transition Metals

  • Tengfei Zhang ,
  • Zhe Chang ,
  • Chunxia Chen ,
  • Jinsong Peng
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  • a College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040
    b Center for Innovative Research in Synthetic Chemistry and Resource Utilization, Northeast Forestry University, Harbin 150040
*E-mail: ;

Received date: 2004-04-04

  Revised date: 2024-07-17

  Online published: 2024-07-25

Supported by

Fundamental Research Funds for the Central Universities(2572023CT12); Natural Science Foundation of Heilongjiang Province(LH2022B003); National Natural Science Foundation of China(32370413); Fundamental Research Funds for Carbon Neutrality(HKF221700013)

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摘要

在有机合成化学中, C—H键的官能团化是一个十分重要的研究领域. 在众多处于不同化学环境的C—H键中, N-α位的Csp3—H键因氮原子的诱导效应使其相较于其他的Csp3—H键具有更高的反应活性, 并且在导向基团作用下可以更好地实现N-α位Csp3—H键的区域选择性官能团化反应, 因此氮原子α位Csp3—H键官能团化是一种非常实用的合成策略, 这为含有氮原子的有机化合物(如尼可刹米、奎宁等)的结构修饰及药物开发提供了更多可能. 综述了近二十年来过渡金属催化氮原子α位Csp3—H键官能团化的发展现状, 并展望了此方法在有机合成化学中的潜力.

关键词： 氮原子; Csp3—H; 官能团化; 过渡金属催化

本文引用格式

张腾飞 , 常喆 , 陈春霞 , 彭进松 . 过渡金属催化氮原子α位Csp3—H键官能团化反应研究进展[J]. 有机化学, 2025 , 45(1) : 168 -188 . DOI: 10.6023/cjoc202404040

Abstract

Functionalization of C—H bonds is a very important research field in organic synthetic chemistry. In many C—H bonds located in different chemical environments, the induced effect of the nitrogen atom makes the α-Csp3—H bond more active compared to other Csp3—H bonds, and the regioselective functionalization of the α-Csp3—H bond is also better achieved with the help of directing groups. Therefore, the functionalization of the α-Csp3—H bond of nitrogen atoms is a very practical synthetic strategy, which provides more possibilities for the structural modification and development of drugs containing nitrogen atoms (such as nicotinamide and quinine). The current development of transition metal-catalyzed functionalization of the α-Csp3—H bond of nitrogen atoms in the past twenty years is reviewed and the potential of this synthetic methodology in the future is looked forward.

Key words： nitrogen atom; Csp3—H; functionalization; transition metal-catalyzed

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