以CO2为C1源合成N-芳基吡咯烷
收稿日期: 2024-05-29
修回日期: 2024-08-22
网络出版日期: 2024-09-10
基金资助
国家重点研发计划(2023YFA1506404); 甘肃省科技计划(23ZDFA003); 甘肃省科技计划(23JRRA1144); 甘肃省科技计划(23JRRA1028); 甘肃省科技计划(23CXGA0043); 兰州市科技计划(2024-1-17); 兰州市科技计划(2023-1-17); 兰州市科技计划(2023-QN-18); 中央高校基本科研业务专项(lzujbky-2022-sp09); 中央高校基本科研业务专项(lzujbky-2023-ct02); 中央高校基本科研业务专项(lzujbky-2023-pd08); 陇药协同创新中心和甘肃省药物研发计(2022GSMPA0010)
Synthesis of N-Arylpyrrolidines Using CO2 as C1 Source
Received date: 2024-05-29
Revised date: 2024-08-22
Online published: 2024-09-10
Supported by
National Key R&D Program of China(2023YFA1506404); Science and Technology Program of Gansu Province(23ZDFA003); Science and Technology Program of Gansu Province(23JRRA1144); Science and Technology Program of Gansu Province(23JRRA1028); Science and Technology Program of Gansu Province(23CXGA0043); Lanzhou Science and Technology Planning Project(2024-1-17); Lanzhou Science and Technology Planning Project(2023-1-17); Lanzhou Science and Technology Planning Project(2023-QN-18); Fundamental Research Funds for the Central Universities(lzujbky-2022-sp09); Fundamental Research Funds for the Central Universities(lzujbky-2023-ct02); Fundamental Research Funds for the Central Universities(lzujbky-2023-pd08); Collaborative Innovation Center for Northwestern Chinese Medicine of Lanzhou University and the Drug Research Project of Gansu Province(2022GSMPA0010)
周于佳 , 孔荞 , 朱道勇 , 王少华 . 以CO2为C1源合成N-芳基吡咯烷[J]. 有机化学, 2024 , 44(10) : 3185 -3197 . DOI: 10.6023/cjoc202405042
A series of N-arylpyrrolidines were synthesized by using carbon dioxide and N-arylpropylamine derivatives as substrates, N-heterocyclic carbene IPr as catalyst, 1,3,5,7-tetramethylcyclotetrasiloxane (TMCTS) as reducing agent, triethylenediamine as base at atmospheric pressure. The reaction features mild conditions, metal-free and good functional group tolerance.
Key words： CO2; N-arylpropylamine; N-arylpyrrolidine
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