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2025 , Vol. 45 >Issue 4: 1379 - 1385

DOI: https://doi.org/10.6023/cjoc202407001

研究论文

硒介导异腈与邻氨基苯酚环化反应合成2-胺基苯并噁唑

  • 王峥 ,
  • 兰羽琴 ,
  • 周芷怡 ,
  • 谭英姿 ,
  • 王宗成
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  • 湖南科技学院化学与生物工程学院 湖南永州 425199

收稿日期: 2024-07-01

  修回日期: 2024-08-18

  网络出版日期: 2024-09-30

基金资助

湖南省自然科学基金(2024JJ7182)

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Selenium Mediated Cyclization Reaction of Isonitriles with o-Aminophenols to Synthesize 2-Aminobenzoxazoles

  • Zheng Wang ,
  • Yuqin Lan ,
  • Zhiyi Zhou ,
  • Yingzi Tan ,
  • Zongcheng Wang
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  • College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan 425199
* E-mail: ;

Received date: 2024-07-01

  Revised date: 2024-08-18

  Online published: 2024-09-30

Supported by

Natural Science Foundation of Hunan Province(2024JJ7182)

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摘要

报道了一种硒粉介导下异腈与邻氨基苯酚进行环化反应合成2-胺基苯并噁唑的方法. 该反应简单地采用硒粉为促进剂, 叔丁醇钠为碱, 在温和条件下实现了多种2-胺基苯并噁唑的绿色、高效构建. 该反应具有操作简便和无金属污染的优点. 该方法还可以实现2-胺基苯并噻唑和2-胺基苯并咪唑的合成.

关键词： 非金属; 硒; 异腈; 邻氨基苯酚; 2-胺基苯并噁唑

本文引用格式

王峥 , 兰羽琴 , 周芷怡 , 谭英姿 , 王宗成 . 硒介导异腈与邻氨基苯酚环化反应合成2-胺基苯并噁唑[J]. 有机化学, 2025 , 45(4) : 1379 -1385 . DOI: 10.6023/cjoc202407001

Abstract

Selenium mediated cyclization reaction of isonitriles with o-aminophenols leading to 2-aminobenzoxazoles has been reported. The present method, which simply utilizes element selenium as promoter and tBuONa as base, provides a green and efficient approach to synthesize various 2-aminobenzoxazoles under mild conditions. This reaction has the advantages of simple operation and metal-free condition. 2-Aminobenzothiazole and 2-aminobenzimidazole could also be synthesized through this methodology.

Key words： metal-free; selenium; isonitriles; o-aminophenols; 2-aminobenzoxazoles

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