2-取代的3H-吲哚-3-酮类化合物参与的C2位手性吲哚啉-3-酮类化合物的不对称合成研究进展
收稿日期: 2024-10-16
修回日期: 2026-11-26
网络出版日期: 2024-12-06
基金资助
云南省基础研究计划(202401AT070041); 云南省教育厅科学研究基金(2024J0564); 云南省教育厅科学研究基金(2024Y456)
Research Progress in Asymmetric Synthesis of C2 Chiral Indolin-3-ones Involving 2-Substituted-3H-indol-3-ones
Received date: 2024-10-16
Revised date: 2026-11-26
Online published: 2024-12-06
Supported by
Yunnan Fundamental Research Projects(202401AT070041); Scientific Research Fund of Education Department of Yunnan Province(2024J0564); Scientific Research Fund of Education Department of Yunnan Province(2024Y456)
含有2,2-二取代吲哚啉-3-酮类骨架的化合物在天然产物、手性药物等诸多领域有着广泛应用. 通过不对称催化高效构建2,2-二取代吲哚啉-3--酮类化合物受到越来越广泛的关注. 综述了近些年国内外在以2-取代的3H-吲哚-3-酮类化合物为底物的不对称催化合成2,2-二取代吲哚啉-3-酮类化合物方面取得的研究进展, 主要从不对称aza- Friedel-Crafts反应、Mannich反应、aza-Diels-Alder反应、aza-Henry反应、aza-Morita-Baylis-Hillman反应以及其他反应等方面进行讨论, 为今后不对称合成C2季碳中心吲哚啉-3-酮类化合物研究提供参考.
关键词： 2-芳基-3H-吲哚-3-酮; 不对称催化; C2季碳中心吲哚啉-3-酮
乔秀秀 , 李倩 , 赵世娜 , 魏瑞琪 , 马桃 , 何永辉 , 赵晓静 . 2-取代的3H-吲哚-3-酮类化合物参与的C2位手性吲哚啉-3-酮类化合物的不对称合成研究进展[J]. 有机化学, 2025 , 45(4) : 1166 -1177 . DOI: 10.6023/cjoc202407039
Compounds containing 2,2-disubstituted indoline-3-one skeletons are widely used in many fields such as natural products and chiral drugs. The efficient construction of 2,2-disubstituted indolin-3-ones by asymmetric catalysis has attracted more and more attention. The research progress in the asymmetric synthesis of 2,2-disubstituted indolin-3-ones using 2-sub- stituted indolin-3-ones as substrates in recent years is reviewed, including asymmetric aza-Friedel-Crafts reaction, Mannich reaction, aza-Diels-Alder reaction, aza-Henry reaction, aza-Morita-Baylis-Hillman reaction and other reactions. It provides a reference for the future asymmetric synthesis of C2 quaternary carbon center indolin-3-one compounds.
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