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2025 , Vol. 45 >Issue 1: 86 - 103

DOI: https://doi.org/10.6023/cjoc202411018

综述与进展

α-三氟甲基酮的合成及其脱氟转化反应研究进展

  • 曹素芳 ,
  • 刘云云 ,
  • 万结平
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  • 江西师范大学化学与材料学院 南昌 330022

收稿日期: 2024-11-22

  修回日期: 2024-12-05

  网络出版日期: 2024-12-12

基金资助

国家自然科学基金(22161022)

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Advances in the Synthesis of α-Trifluoromethyl Ketones and Their Application via Defluorinative Reactions

  • Sufang Cao ,
  • Yunyun Liu ,
  • Jieping Wan
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  • College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022
*E-mail:

Received date: 2024-11-22

  Revised date: 2024-12-05

  Online published: 2024-12-12

Supported by

National Natural Science Foundation of China(22161022)

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摘要

α-三氟甲基酮是一类重要且功能多样的化合物. 该类化合物通过碳-氟键官能化在有机合成中具有独特而有趣的应用, 可用于合成具有结构多样的有机分子. 综述了α-三氟甲基酮的合成及其脱氟官能化转化反应的研究进展. 对于典型的反应, 进行了反应机理方面的讨论, 旨在为α-三氟甲基酮化学, 包括它们本身以及由此衍生的产物合成提供参考.

关键词： α-三氟甲基酮; 合成方法; 合成应用; 脱氟; 串联反应

本文引用格式

曹素芳 , 刘云云 , 万结平 . α-三氟甲基酮的合成及其脱氟转化反应研究进展[J]. 有机化学, 2025 , 45(1) : 86 -103 . DOI: 10.6023/cjoc202411018

Abstract

α-Trifluoromethyl ketones are a class of useful compounds with versatile applications. Their synthetic application via the transformation of the C—F bonds is of particular interest by allowing the synthesis of organic compounds with diverse structures. Herein, the advances in the research areas of α-trifluoromethyl ketone synthesis and their defluorination reactions are reviewed. Discussion on the mechanisms of the typical reactions has also been provided, in hope of affording some guides to the chemistry of α-trifluoromethyl ketones in the synthetic methods toward themselves and their derivatives.

Key words： α-trifluoromethyl ketone; synthetic method; synthetic application; defluorination; cascade reaction

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