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DOI: https://doi.org/10.6023/cjoc202411004

研究论文

布朗斯特酸催化下硫代羧酸与（氮杂）邻亚甲基醌的共轭加成反应

  • 薛秀 ,
  • 杨惠儿 ,
  • 黄泽深 ,
  • 郎明 ,
  • 刘文锋
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  • 五邑大学药学与食品工程学院 江门 529020

收稿日期: 2025-01-23

  修回日期: 2025-02-21

  网络出版日期: 2025-03-13

基金资助

五邑大学高层次人才启动经费项目(No. 2019AL025)资助项目; 江门市基础与理论科学研究类科技计划项目(2022JC01013)资助项目.

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Brønsted Acid Catalyzed Conjugate Addition of Thiocarboxylic Acids to In Situ-Generated (aza-)ortho-Quinone Methides

  • Xue Xiu ,
  • Yang Huier ,
  • Huang Zeshen ,
  • Lang Ming ,
  • Liu Wenfeng
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  • Wuyi University, School of Pharmacy and Food Engineering, Jiangmen, 529020

Received date: 2025-01-23

  Revised date: 2025-02-21

  Online published: 2025-03-13

Supported by

High-Level Talent Research Start-up Project of Wuyi University (No. 2019AL025), the Jiangmen City Science and Technology Basic Research Project (No. 2022JC01013).

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摘要

报道了一种布朗斯特酸催化下硫代羧酸与原位生成的邻亚甲基醌和氮杂邻亚甲基醌之间的共轭加成反应. 该反应具有底物适用范围广、反应条件温和、操作简单、产率高的优点, 为在温和条件下高效构建具有结构多样性的硫酯类化合物提供了新的方法.

关键词： 邻亚甲基醌; 氮杂邻亚甲基醌; 硫代羧酸; 共轭加成

本文引用格式

薛秀 , 杨惠儿 , 黄泽深 , 郎明 , 刘文锋 . 布朗斯特酸催化下硫代羧酸与（氮杂）邻亚甲基醌的共轭加成反应[J]. 有机化学, 0 : 202411004 -202411004 . DOI: 10.6023/cjoc202411004

Abstract

An efficient Brønsted acid catalyzed conjugate addition of thiocarboxylic acids to in situ-generated ortho-quinone methides (o-QMs) and aza-ortho-quinone methides (aza-o-QMs) has been reported. The reaction has the advantages of broad substrate scope, mild reaction conditions, easy operation and excellent yield. This study provides a new synthetic methodology for the efficient construction of structurally diverse thioesters under mild conditions.

Key words： ortho-Quinone methides; aza-ortho-Quinone methides; Thiocarboxylic acids; Conjugate addition

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