布朗斯特酸催化下硫代羧酸与（氮杂）邻亚甲基醌的共轭加成反应

doi:10.6023/cjoc202411004

摘要/Abstract

报道了一种布朗斯特酸催化下硫代羧酸与原位生成的邻亚甲基醌和氮杂邻亚甲基醌之间的共轭加成反应. 该反应具有底物适用范围广、反应条件温和、操作简单、产率高的优点, 为在温和条件下高效构建具有结构多样性的硫酯类化合物提供了新的方法.

An efficient Brønsted acid catalyzed conjugate addition of thiocarboxylic acids to in situ-generated ortho-quinone methides (o-QMs) and aza-ortho-quinone methides (aza-o-QMs) has been reported. The reaction has the advantages of broad substrate scope, mild reaction conditions, easy operation and excellent yield. This study provides a new synthetic methodology for the efficient construction of structurally diverse thioesters under mild conditions.

Key words: ortho-Quinone methides, aza-ortho-Quinone methides, Thiocarboxylic acids, Conjugate addition

引用此文

薛秀, 杨惠儿, 黄泽深, 郎明, 刘文锋. 布朗斯特酸催化下硫代羧酸与（氮杂）邻亚甲基醌的共轭加成反应[J]. 有机化学, doi: 10.6023/cjoc202411004.

Xue Xiu, Yang Huier, Huang Zeshen, Lang Ming, Liu Wenfeng. Brønsted Acid Catalyzed Conjugate Addition of Thiocarboxylic Acids to In Situ-Generated (aza-)ortho-Quinone Methides[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202411004.

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