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DOI: https://doi.org/10.6023/cjoc202509013

研究论文

芳基亚磺酸钠与芳基硫鎓盐的脱硫交叉偶联反应

  • 梁新宇 ,
  • 米春春 ,
  • 郭福军 ,
  • 谢文斌 ,
  • 史钦钦 ,
  • 黄辉
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  • a中国科学院大学材料科学与光电技术学院 北京 101408;
    b天津大学化工学院, 化学工程与低碳技术全国重点实验室 天津 300072
†共同第一作者

收稿日期: 2025-09-09

  修回日期: 2025-11-06

  网络出版日期: 2025-12-10

基金资助

国家自然科学基金(NO. 52222309, NO. 52173187, NO. 52303019, NO. 52450063)、北京自然科学基金（Z210017）、中国科学院战略性先导科技专项（XDB 0520103）、中国科学院国际伙伴计划（124GJHZ2023079MI）、中国博士后科学基金（2024T170904）和中央高校基本科研业务费专项资金资助项目.

收起

Desulfinative Cross-coupling of Aryl Sodium Sulfinate with Aryl Sulfonium Salts

  • Xinyu Liang ,
  • Chunchun Mi ,
  • Fujun Guo ,
  • Wenbin Xie ,
  • Qinqin Shi ,
  • Hui Huang
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  • aCollege of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 101408,China;
    bSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Tianjin University, Tianjin, 300072, China
†The authors contributed equally to this work.

Received date: 2025-09-09

  Revised date: 2025-11-06

  Online published: 2025-12-10

Supported by

NSFC (NO. 52222309, NO. 52173187, NO. 52303019, and NO. 52450063), Beijing Natural Science Foundation (Z210017), The Strategic Priority Research Program of Chinese Academy of Sciences (XDB 0520103), the International Partnership Program of Chinese Academy of Sciences (124GJHZ2023079MI), China Postdoctoral Science Foundation (2024T170904), and Fundamental Research Funds for the Central Universities.

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摘要

过渡金属催化的交叉偶联反应是有机合成中构建碳-碳键的核心策略。本研究开发了钯催化下芳基亚磺酸钠与芳基硫鎓盐的交叉偶联反应,该反应通过间断Pummerer活化C-H键实现。通过筛选多种芳基亚磺酸钠和芳基硫鎓盐,验证了该方法的稳定性。需要特别说明的是,两个药物后期功能化的案例充分展示了其在药物开发中的应用潜力。

关键词： 过渡金属催化; 脱硫偶联; C-H活化; 药物后修饰

本文引用格式

梁新宇 , 米春春 , 郭福军 , 谢文斌 , 史钦钦 , 黄辉 . 芳基亚磺酸钠与芳基硫鎓盐的脱硫交叉偶联反应[J]. 有机化学, 0 : 9013 . DOI: 10.6023/cjoc202509013

Abstract

Transition-metal-catalyzed cross-coupling reactions represent a cornerstone strategy for C-C bond formation in organic synthesis. Herein, a Pd-catalyzed cross-coupling of aryl sodium sulfinates and aryl sulfonium salts via the interrupted Pummerer activation was developed. A variety of sodium sulfinates and aryl sulfonium salts were screened to show robustness of this method. Notably, two examples of late-stage functionalization of drugs exemplified the potentials application in drugs.

Key words： transition metal catalysis; desulfinative coupling; C-H activation; post-modification of pharmaceuticals

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