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DOI: https://doi.org/10.6023/cjoc202603003

研究论文

紫外光驱动的芳香醛与邻氨基苯甲酰胺构建喹唑啉酮化合物

  • 冯亚栋 ,
  • 毕寺恒 ,
  • 唐明清 ,
  • 吴养洁 ,
  • 皮超
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  • a河南省化学生物学与有机化学重点实验室 河南省高校应用化学重点实验室 平原实验室 炼焦煤资源绿色开发全国重点实验室 郑州大学化学学院 郑州大学 郑州 450052;
    b天然化妆品福建省高校工程研究中心 公共卫生与医学技术学院 厦门医学院 厦门 361023;
    c分子药物教育部工程研究中心 福建省分子医学重点实验室 福建省高校精准医学与分子诊断重点实验室 厦门市海洋与基因药物重点实验室 华侨大学生物医学学院 华侨大学 厦门 361021

收稿日期: 2026-03-03

  修回日期: 2026-04-24

  网络出版日期: 2026-05-27

基金资助

河南省自然科学基金（No. 252300423136）、福建省自然科学基金 (No. 2025J011469)、厦门市自然科学基金 (No. 3502Z202372064)资助项目.

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UV-Light-Driven Construction of Quinazolinones from Aryl Aldehydes and Anthranilamides

  • Feng Yadong ,
  • Bi Siheng ,
  • Tang Mingqing ,
  • Wu Yangjie ,
  • Pi Chao
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  • aHenan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Pingyuan Laboratory, State Key Laboratory of Coking Coal Resources Green Exploitation and College of Chemistry, Zhengzhou University, Zhengzhou 450052;
    bEngineering Research Center of Natural Cosmeceuticals College of Fujian Province, Department of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023;
    cEngineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021

Received date: 2026-03-03

  Revised date: 2026-04-24

  Online published: 2026-05-27

Supported by

Natural Science Foundation of Henan (No. 252300423136),Natural Science Foundation of Fujian Province,China (No. 2025J011469), and the Natural Science Foundation of Xiamen, China (No. 3502Z202372064)

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摘要

本文报道了一种在无外加光催化剂条件下构建喹唑啉酮骨架的紫外光驱动策略。廉价易得的叔丁基过氧化氢（TBHP）作为自由基引发剂,在紫外光照射下促进邻氨基苯甲酰胺与芳香醛之间的自由基参与偶联/环化串联反应,从而高效获得一系列喹唑啉酮衍生物。该方法具有操作简便、原料来源广泛且易得、转化效率良好等优点,同时避免了过渡金属和外加光催化剂的使用。因此,该方法为喹唑啉酮骨架的绿色可持续合成提供了一种有价值的补充途径;喹唑啉酮骨架也是一类具有药物相关意义的重要结构单元。

关键词： 紫外光; 无光催化剂; 喹唑啉酮

本文引用格式

冯亚栋 , 毕寺恒 , 唐明清 , 吴养洁 , 皮超 . 紫外光驱动的芳香醛与邻氨基苯甲酰胺构建喹唑啉酮化合物[J]. 有机化学, 0 : 202603003 -202603003 . DOI: 10.6023/cjoc202603003

Abstract

Herein, we report a UV-light-driven strategy for the construction of quinazolinone frameworks under photocatalyst-free conditions. Readily available and inexpensive tert-butyl hydroperoxide (TBHP) serves as a radical initiator to promote a radical-involved coupling/cyclization cascade between o-aminobenzamides and aryl aldehydes under UV irradiation, affording a range of quinazolinone derivatives efficiently. This protocol features operational simplicity, high feedstock accessibility, and good conversion efficiency, while avoiding the use of transition metals and external photocatalysts. As such, it provides a valuable complementary approach to the green and sustainable synthesis of quinazolinone scaffolds, an important class of pharmaceutical relevant scaffolds.

Key words： UV-light; photocatalyst-free; quinazolinones

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