对海洋来源真菌Talaromyces sp. F017-1-114的次级代谢产物进行研究,从中分离得到了两个新的氧杂蒽酮衍生物（1和2）和一个新的没药烷型倍半萜（3）以及6个已知的多羟基氧杂蒽酮（4-9）。通过高分辨电喷雾质谱、核磁共振波谱、铜靶X射线单晶衍射分析以及ECD曲线计算确定了新化合物的结构。体外抗菌活性结果显示,化合物5和6对青枯雷尔氏菌ATCC11696表现出中等的抗菌活性,其最小抑菌浓度分别为25 µg/mL和12.5 µg/mL。化合物3对金黄色葡萄球菌ATCC25923显示出较弱的抗菌活性,最小抑菌浓度为50 µg/mL。
何勇
,
张亚亚
,
符霖
,
邓璐楠
,
陈光英
,
黎婉珊
. 海洋来源真菌Talaromyces sp. F017-1-114次级代谢产物与其抗菌活性研究[J]. 有机化学, 0
: 202604035
-202604035
.
DOI: 10.6023/cjoc202604035
Chemical investigation on a marine-derived fungus Talaromyces sp. F017-1-114 led to isolation of two new xanthone derivatives (1 and 2), one new bisabolane-type sesquiterpene (3), and six known polyhydroxanthones (4-9). The structures of the new compounds were demonstrated by HRESIMS, extensive NMR investigations, single-crystal X-ray diffraction analysis with Cu Kα radiation, and electronic circular dichroism (ECD) calculations. Among them, compounds 5 and 6 showed moderate antimicrobial activities against Ralstonia solanacearum ATCC11696 with MIC values of 25 and 12.5 µg/mL, respectively. Compound 3 exhibited weak antibacterial activity against Staphylococcus aureus ATCC25923 with an MIC value of 50 µg/mL.
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