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DOI: https://doi.org/10.6023/cjoc202605014

综述与进展

烯烃的催化不对称双卤化研究进展

  • Li ,
  • Jing
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  • a常州大学 石油化工学院 江苏 常州 213164;
    b常州大学 自然与合成有机化学研究院 江苏 常州 213164

收稿日期: 2026-05-14

  修回日期: 2026-06-27

  网络出版日期: 2026-08-28

基金资助

国家自然科学基金(No. 22401021)资助项目.

收起

Recent Advances in Catalytic Asymmetric Dihalogenation of Alkenes

  • 李静
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  • a School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164;
    b Institute of Natural and Synthetic Organic Chemistry, Changzhou University, Changzhou, Jiangsu 213164

Received date: 2026-05-14

  Revised date: 2026-06-27

  Online published: 2026-08-28

Supported by

National Natural Science Foundation of China (No. 22401021).

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摘要

手性双卤骨架存在于多种具有抑菌、抗肿瘤的生物活性分子中,在医药、合成化学领域应用广泛。基于手性双卤化合物的重要性,发展精准、高效、绿色的合成手性双卤化合物的方法是有机合成化学中的重要课题之一。近年来,通过烯烃的催化不对称双卤化合成手性双卤化合物得到了广泛关注。本文主要综述了不同催化体系下烯烃的催化不对称双卤化的研究进展,主要包括手性路易斯碱催化、手性路易斯酸催化、手性有机碘催化3种反应体系,并对烯烃不对称双卤化的难点、挑战和未来发展方向进行了谈论。

关键词： 催化; 烯烃; 不对称双卤化

本文引用格式

Li , Jing . 烯烃的催化不对称双卤化研究进展[J]. 有机化学, 0 : 0 . DOI: 10.6023/cjoc202605014

Abstract

Chiral dihalogen skeletons are encountered in the structure of numerous bioactive compounds with antibacterial and antitumour activities, and widely used in the field of medicine and synthetic chemistry. Based on the importance of chiral dihalides, it is one of the important topics in organic synthetic chemistry to develop accurate, efficient, and green methods to synthesize chiral dihalides. In recent years, the synthesis of chiral dihalides by catalytic asymmetric dihalogenation of olefins has attracted great attention. Three different catalytic systems on asymmetric dihalogenation of alkenes is reviewed, including chiral Lewis base catalysis, chiral Lewis acid catalysis, and chiral organic iodine catalysis. Furthermore, the difficulties, challenges, and future development of asymmetric dihalogenation of alkenes are also discussed.

Key words： catalytic; alkene; asymmetric dihalogenation

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