烯烃的催化不对称双卤化研究进展

doi:10.6023/cjoc202605014

摘要/Abstract

手性双卤骨架存在于多种具有抑菌、抗肿瘤的生物活性分子中,在医药、合成化学领域应用广泛。基于手性双卤化合物的重要性,发展精准、高效、绿色的合成手性双卤化合物的方法是有机合成化学中的重要课题之一。近年来,通过烯烃的催化不对称双卤化合成手性双卤化合物得到了广泛关注。本文主要综述了不同催化体系下烯烃的催化不对称双卤化的研究进展,主要包括手性路易斯碱催化、手性路易斯酸催化、手性有机碘催化3种反应体系,并对烯烃不对称双卤化的难点、挑战和未来发展方向进行了谈论。

关键词: 催化, 烯烃, 不对称双卤化

Chiral dihalogen skeletons are encountered in the structure of numerous bioactive compounds with antibacterial and antitumour activities, and widely used in the field of medicine and synthetic chemistry. Based on the importance of chiral dihalides, it is one of the important topics in organic synthetic chemistry to develop accurate, efficient, and green methods to synthesize chiral dihalides. In recent years, the synthesis of chiral dihalides by catalytic asymmetric dihalogenation of olefins has attracted great attention. Three different catalytic systems on asymmetric dihalogenation of alkenes is reviewed, including chiral Lewis base catalysis, chiral Lewis acid catalysis, and chiral organic iodine catalysis. Furthermore, the difficulties, challenges, and future development of asymmetric dihalogenation of alkenes are also discussed.

Key words: catalytic, alkene, asymmetric dihalogenation

引用此文

李静. 烯烃的催化不对称双卤化研究进展[J]. 有机化学, doi: 10.6023/cjoc202605014.

Li, Jing. Recent Advances in Catalytic Asymmetric Dihalogenation of Alkenes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202605014.

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