Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (01): 193-196.DOI: 10.6023/cjoc1105133 Previous Articles     Next Articles



田金金, 郭红云   

  1. 浙江工业大学化学工程与材料学院 杭州 310014
  • 收稿日期:2011-05-13 修回日期:2011-09-03 发布日期:2011-09-08
  • 通讯作者: 郭红云

One-Pot Synthesis of 2-Amino-4-phenyl-6-(phenylsulfanyl)-3,5-dicyanopyridines in Ionic Liquids

Tian Jinjin, Guo Hongyun   

  1. College of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2011-05-13 Revised:2011-09-03 Published:2011-09-08
  • Contact: Guo Hongyun

The one-pot reaction of aldehydes, malononitrile and thiols was investigated in different medium. It was found that in ionic liquid [bmim]BF4 this reaction could be finished in short time and gave the product 2-amino-4-phenyl-6-(phenylsulfanyl)- 3,5-dicyanopyridines in high yields without byproduct. This method has some distinct advantages such as mild reaction conditions, high yields and selectivity, environmental friendliness. Moreover, the ionic liquid could be recovered conveniently and reused.

Key words: aldehyde, malononitrile, thiol, ionic liquid, 2-amino-4-phenyl-6-(phenylsulfanyl)-3,5-dicyanopyridine