Progress in Total Syntheses of Lindenane-Type Sesquiterpenoids and Their Dimers

doi:10.6023/cjoc201207003

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 90-100.DOI: 10.6023/cjoc201207003 Previous Articles Next Articles

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乌药烷型倍半萜及其二聚体的全合成研究进展

乐贵洲^a,c, 杨立^a, 袁长春^a, 杜彪^a, 刘波^a,b

a 四川大学化学学院绿色化学与技术教育部重点实验室成都 610064;
b 中国科学院上海有机化学研究所中国科学院天然产物合成化学重点实验室上海 200032;
c 四川农业大学生命科学与理学院雅安 625014

收稿日期:2012-07-03 修回日期:2012-08-31 发布日期:2012-09-05
通讯作者: 刘波 E-mail:chembliu@scu.edu.cn
基金资助:
国家自然科学基金(Nos. 20872098, 21021001, 21172154);国家重点基础研究发展规划(973计划, No. 2010CB833200).

Progress in Total Syntheses of Lindenane-Type Sesquiterpenoids and Their Dimers

Yue Guizhou^a,c, Yang Li^a, Yuan Changchun^a, Du Biao^a, Liu Bo^a,b

a Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064;
b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
c School of Life and Science, Sichuan Agricultural University, Ya'an 625014

Received:2012-07-03 Revised:2012-08-31 Published:2012-09-05
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 20872098, 21021001, 21172154), the National Basic Research Program of China (973 Program, No. 2010CB833200).

Lindenane-type sesquteripenoids and their dimers, mainly isolated from chloranthaceae, are a big family of natural products, which possess novel polycyclic framework embedded with a sterically congested cyclopentane (ring B), an unusual trans-5/6 ring junction, and an angular methyl group. Moreover, many of them exhibited impressing bioactivities, for example remarkable antifungal activity, toxicity-mediated immunosuppression against B cells, and selective inhibition on the delayed rectifier K⁺current. In this review, the progress in the total syntheses of lindenane-type sesquiterpenoids and their dimmers is summarized.

Key words: lindenane, sesquiterpenoid, dimer, total synthesis

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Yue Guizhou, Yang Li, Yuan Changchun, Du Biao, Liu Bo. Progress in Total Syntheses of Lindenane-Type Sesquiterpenoids and Their Dimers[J]. Chin. J. Org. Chem., 2013, 33(01): 90-100.

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乌药烷型倍半萜及其二聚体的全合成研究进展

Progress in Total Syntheses of Lindenane-Type Sesquiterpenoids and Their Dimers

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