Recent Advances in C—H Functionalizations Assisted by Removable and/or Modifiable Directing Groups

doi:10.6023/cjoc201308012

Abstract

Transition-metal catalyzed chelation-assisted C—H bond functionalization is one of hot topics in current organic chemistry. Recently, using removable and/or modifiable directing groups for C—H bond functionalizations has being received specially attention and developed rapidly. By taking advantage of removable and/or modifiable directing groups, it not only greatly expands the scope of substrates for C—H fuctionalization, but also plays important roles in rapid construction of molecule diversity. Based on the classification according to different hetero-atom (N, O, S, and Si) donors, this review presents the state of the art in design of removable and/or modifiable directing groups for transition-metal catalyzed C—H functionalizations and their application in construction of molecule diversity. Finally, the existing problems and limitations of this field are summarized, and the outlook of the area is also prospected.

Key words: directing group, C—H bond functionalization, transition-metal catalysis, molecule diversity

Cite this article

Zhang Wei, Zhang Jiahui, Liu Yunkui. Recent Advances in C—H Functionalizations Assisted by Removable and/or Modifiable Directing Groups[J]. Chin. J. Org. Chem., 2014, 34(1): 36-53.

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可离去和/或可修饰导向基团辅助的C—H键官能化反应研究进展