Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (7): 1442-1446.DOI: 10.6023/cjoc201401035 Previous Articles     Next Articles

Notes

5-核糖或木糖亚甲基-2,4-咪唑啉二酮衍生物的合成及其杀菌活性

刘斌, 韩金涛, 汤博, 王明安   

  1. 中国农业大学应用化学系 北京 100193
  • 收稿日期:2014-01-21 修回日期:2014-03-05 发布日期:2014-04-15
  • 通讯作者: 王明安 E-mail:wangma@cau.edu.cn
  • 基金资助:

    “十二五”科技支撑计划(No.2011BAE06B03)资助项目.

Synthesis and Fungicidal Activity of D-Ribose and D-Xylose with Hydantion

Liu Bin, Han Jintao, Tang Bo, Wang Mingan   

  1. Department of Applied Chemistry, China Agricultural University, Beijing 100193
  • Received:2014-01-21 Revised:2014-03-05 Published:2014-04-15
  • Supported by:

    Project supported by the National Key Technologies R&D Program (No. 2011BAE06B03).

The α-D-ribose and α-D-xylose C(5)-aldehyde derivatives (1 and 2) were prepared through four and two steps using 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose as raw material. Then 1 and 2 reacted with hydantoin phosphonate and 2-thiohydantoin by Wittig-Horner and Knoevenagel reaction to afford 3 pairs of E and Z isomers of target products 35. Their structures were elucidated by 1H NMR, 13C NMR, IR, MS and X-ray diffraction. The preliminary bioassay results showed that some of them have certain fungicidal activities against 7 plant pathogens at the concentration of 50 μg/mL.

Key words: hydantoin, ribose, xylose, fungicidal activity