Copper Mediated One-Pot Multi-Component Synthesis of 3-Substitued Isoquinolines

doi:10.6023/cjoc201606023

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (12): 2906-2911.DOI: 10.6023/cjoc201606023 Previous Articles Next Articles

ARTICLE

CuI促进的多组分一锅法合成3-取代异喹啉衍生物

张锐^a, 潘金环^a, 吴琼友^a

a 华中师范大学化学学院农药与化学生物学教育部重点实验室武汉 430079

收稿日期:2016-06-14 修回日期:2016-07-20 发布日期:2016-08-25
通讯作者: 吴琼友 E-mail:qywu@mail.ccnu.edu.cn
基金资助:
国家自然科学基金（No. 21272091）、华中师范大学中央高校基本科研业务费（No. CCNU15A02014）资助项目.

Copper Mediated One-Pot Multi-Component Synthesis of 3-Substitued Isoquinolines

Zhang Rui^a, Pan Jinhuan^a, Wu Qiongyou^a

a Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079

Received:2016-06-14 Revised:2016-07-20 Published:2016-08-25
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21272091) and the Self-determined Research Funds of Central China Normal University from the Colleges' Basic Research and Operation of Ministry of Education (No. CCNU15A02014).

In this paper, a CuI mediated one-pot muti-component method for the preparation of isoquinoline derivatives under microwave irradiation was developed by using 2-bromobenzaldehyde and terminal alkynes as starting materials, tert-butyl amine as nitrogen source. This methodology provides one convenient and high efficient approach to the 3-substituted isoquinoline library.

Key words: 3-substituted isoquinolines, copper iodide, microwave irradiation, multiple component reaction

Cite this article

Zhang Rui, Pan Jinhuan, Wu Qiongyou. Copper Mediated One-Pot Multi-Component Synthesis of 3-Substitued Isoquinolines[J]. Chin. J. Org. Chem., 2016, 36(12): 2906-2911.

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CuI促进的多组分一锅法合成3-取代异喹啉衍生物

Copper Mediated One-Pot Multi-Component Synthesis of 3-Substitued Isoquinolines

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