Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3186-3190.DOI: 10.6023/cjoc201705017 Previous Articles     Next Articles



王力耕, 陈璐焌, 章华隆, 余琴   

  1. 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2017-05-11 修回日期:2017-07-07 发布日期:2017-09-08
  • 通讯作者: 王力耕

Selective Oxidative Bromination of Anilines Using Potassium Bromide and ZnAl-BrO3--LDHs

Wang Ligeng, Chen Lujun, Zhang Hualong, Yu Qin   

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2017-05-11 Revised:2017-07-07 Published:2017-09-08
  • Contact: 10.6023/cjoc201705017

The oxidative bromination of anilines was realized with ZnAl-BrO3--LDHs/KBr as the bromine source at ambient temperature in acidic medium (AcOH/H2O). High yields of monobrominated or polybrominated anilines were achieved for a wide range of anilines. Both the substrate structure and the reaction conditions will significantly influence the reaction selectivity. The use of inexpensive reagents, environmentally benign and operationally simple process, and excellent yields make it a good alternative to the synthesis of bromoanilines.

Key words: anilines, halogenation, selectivity, aromatic substitution