Recent Advances of α-Aryl Vinyl Azides in Nitrogen Heterocycle Synthesis

doi:10.6023/cjoc201709025

Abstract

Nitrogen heterocyclic compounds can be found in various natural products, pharmaceutical chemistry and material chemistry. Due to azide group linked to olefins, α-aryl vinyl azide has unique properties, which can act as electrophilic reagents, nucleophilic reagent, or radical acceptor. Diverse reaction pathways of α-aryl vinyl azide provide great opportunities to generate highly reactive intermediates with unusual or unconventional reactivities, making it possible to develop novel reaction. Recently, more and more synthetic chemists used α-aryl vinyl azide as a key three atoms synthon for the construction of diverse structurally complex N-heterocyclic compounds. This review will introduce systematically the reactivities of α-aryl vinyl azide and the developments of the recent application of α-aryl vinyl azide in nitrogen heterocycle synthesis, including mechanism, reaction characteristics and application study, thus it may be helpful for the research on nitrogen heterocycle synthesis.

Key words: α-aryl vinyl azide, synthon, nitrogen heterocyclic compounds, application

Cite this article

Yan Jun, Ji Xiaoyue, Hua Shugui, Wang Jing. Recent Advances of α-Aryl Vinyl Azides in Nitrogen Heterocycle Synthesis[J]. Chin. J. Org. Chem., 2018, 38(4): 791-801.

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