Synthesis and Cytotoxicity of Dinaphtho [2, 1-b: 1', 2'-d]furan Derivatives

doi:10.6023/cjoc201712018

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1516-1524.DOI: 10.6023/cjoc201712018 Previous Articles Next Articles

Articles

二萘并呋喃衍生物的合成及其抗肿瘤活性研究

宋永彬^a,b, 李丹^b, 杨异卉^b, 纪红蕊^a, 刘波^a

a 哈尔滨理工大学化学与环境工程学院哈尔滨 150040;
b 哈尔滨医科大学药学院哈尔滨 150081

收稿日期:2017-12-10 修回日期:2018-01-22 发布日期:2018-02-06
通讯作者: 杨异卉,E-mail:yangyihui19790508@sina.com E-mail:yangyihui19790508@sina.com
基金资助:
黑龙江省青年科学基金（No.QC2014C091）、黑龙江省普通本科高等学校青年创新人才培养计划（No.324015507）、黑龙江省博士后科研启动金（No.LBH-Q16187）资助项目.

Synthesis and Cytotoxicity of Dinaphtho [2, 1-b: 1', 2'-d]furan Derivatives

Song Yongbin^a,b, Li Dan^b, Yang Yihui^b, Ji Hongrui^a, Liu Bo^a

a School of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040;
b College of Pharmacy, Harbin Medical University, Harbin 150081

Received:2017-12-10 Revised:2018-01-22 Published:2018-02-06
Contact: 10.6023/cjoc201712018 E-mail:yangyihui19790508@sina.com
Supported by:
Project supported by the Youth Science Fund of Heilongjiang Province (No. QC2014C091), the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province (No. 324015507) and the Heilongjiang Postdoctoral Scientific Research Developmental Fund (No. LBH-Q16187).

1. Synthesis and Cytotoxicity of Dinaphtho [2, 1-b: 1', 2'-d]furan Derivatives.PDF(993KB)

Abstract

In order to study the structure-activity relationships of dinaphthofuran derivatives, two series of dinaphtho[2,1-b:1', 2'-d]furan derivatives were synthesized. The structures of all compounds were identified by ¹H NMR, ¹³C NMR, HRMS and IR spectra. The in vitro antitumor activity of the synthesized derivatives was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Most of them exhibited strong inhibitory activity on human hepatocellular carcinoma cell lines (HepG2 and SMMC-7721 cells), uterine cervix cancer Hela cells and acute promyelocytic leukemia NB4 cells. Compound 13k exhibited significant inhibitory activity against SMMC-7721 cells with IC₅₀ vaue of 0.57 μmol·L^-1, much lower than 20.21 μmol·L^-1 of the positive control 5-Fu.

Key words: synthesis design, cytotoxicity, dinaphthofuran, NMR spectroscopy

Cite this article

Song Yongbin, Li Dan, Yang Yihui, Ji Hongrui, Liu Bo. Synthesis and Cytotoxicity of Dinaphtho [2, 1-b: 1', 2'-d]furan Derivatives[J]. Chin. J. Org. Chem., 2018, 38(6): 1516-1524.

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二萘并呋喃衍生物的合成及其抗肿瘤活性研究

Synthesis and Cytotoxicity of Dinaphtho [2, 1-b: 1', 2'-d]furan Derivatives

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