Supramolecular Drug Inclusion Complex Constructed from Tetrame-thyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions

doi:10.6023/cjoc201804008

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 1972-1976.DOI: 10.6023/cjoc201804008 Previous Articles Next Articles

Special Issue: 有机超分子化学合辑

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对称四甲基六元瓜环与卡培他滨通过主客体作用构筑的超分子药物包结配合物

张智睿^a, 阚京兰^b, 冯华明^c, 刘青云^d, 陶朱^c, 肖昕^c

a 重庆第九人民医院儿童综合科重庆 400700;
b 山东师范大学学化学化工与材料科学学院济南 250014;
c 贵州大学贵州省大环化学及超分子化学重点实验室贵阳 550025;
d 山东科技大学化学与环境工程学院青岛 266590

收稿日期:2018-04-04 修回日期:2018-05-17 发布日期:2018-06-06
通讯作者: 肖昕 E-mail:gyhxxiaoxin@163.com
基金资助:
贵州省科学技术基金（No.2016-1030）、贵州省高层次创新型人才培养计划（No.2016-5657）和贵州省教育厅创新群体重大研究（No.2017-028）资助项目.

Supramolecular Drug Inclusion Complex Constructed from Tetrame-thyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions

Zhang Zhirui^a, Kan Jinglan^b, Feng Huaming^c, Liu Qingyun^d, Tao Zhu^c, Xiao Xin^c

a Department of Pediatric, The Ninth People's Hospital of Chongqing, Chongqing 400700;
b College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014;
c Key Laboratory of Macrocyclic and Supramolecular Chenmistry of Guizhou Province, Guiyang 550025;
d College of Chemistry and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590

Received:2018-04-04 Revised:2018-05-17 Published:2018-06-06
Contact: 10.6023/cjoc201804008 E-mail:gyhxxiaoxin@163.com
Supported by:
Project supported by the Science and Technology Fund of Guizhou Province (No. 2016-1030), the Innovation Program for High-Level Talents of Guizhou Province (No. 2016-5657) and the Major Program for Creative Research Groups of Guizhou Provincial Education Department (No. 2017-028).

1. Supramolecular Drug Inclusion Complex Constructed from Tetrame-thyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions.PDF(206KB)

Abstract

A novel supramolecular host-guest complex of the anticancer drug capecitabine (CAP) with symmetrical α, α',δ, δ'-tetramethyl-cucurbit[6]uril (TMeQ[6]) has been characterized using nuclear magnetic resonance spectroscopy, MALDI-TOF mass spectrometry, isothermal titration calorimetryand fluorescence spectroscopy analyses. The result revealed that the alkyl chain of CAP is located inside the cavities of TMeQ[6], whereas the other part of CAP remains outside the portal. Our results suggest that TMeQ[6] could be a promising candidate for use as an excipient in the pharmaceutical and medical research ?elds.

Key words: supramolecular, host-guest, cucurbit[n]uril, capecitabine, self-assembly

Cite this article

Zhang Zhirui, Kan Jinglan, Feng Huaming, Liu Qingyun, Tao Zhu, Xiao Xin. Supramolecular Drug Inclusion Complex Constructed from Tetrame-thyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions[J]. Chin. J. Org. Chem., 2018, 38(8): 1972-1976.

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对称四甲基六元瓜环与卡培他滨通过主客体作用构筑的超分子药物包结配合物

Supramolecular Drug Inclusion Complex Constructed from Tetrame-thyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions

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