Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 1972-1976.DOI: 10.6023/cjoc201804008 Previous Articles     Next Articles

Special Issue: 有机超分子化学合辑



张智睿a, 阚京兰b, 冯华明c, 刘青云d, 陶朱c, 肖昕c   

  1. a 重庆第九人民医院儿童综合科 重庆 400700;
    b 山东师范大学学化学化工与材料科学学院 济南 250014;
    c 贵州大学贵州省大环化学及超分子化学重点实验室 贵阳 550025;
    d 山东科技大学化学与环境工程学院 青岛 266590
  • 收稿日期:2018-04-04 修回日期:2018-05-17 发布日期:2018-06-06
  • 通讯作者: 肖昕
  • 基金资助:


Supramolecular Drug Inclusion Complex Constructed from Tetrame-thyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions

Zhang Zhiruia, Kan Jinglanb, Feng Huamingc, Liu Qingyund, Tao Zhuc, Xiao Xinc   

  1. a Department of Pediatric, The Ninth People's Hospital of Chongqing, Chongqing 400700;
    b College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014;
    c Key Laboratory of Macrocyclic and Supramolecular Chenmistry of Guizhou Province, Guiyang 550025;
    d College of Chemistry and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590
  • Received:2018-04-04 Revised:2018-05-17 Published:2018-06-06
  • Contact: 10.6023/cjoc201804008
  • Supported by:

    Project supported by the Science and Technology Fund of Guizhou Province (No. 2016-1030), the Innovation Program for High-Level Talents of Guizhou Province (No. 2016-5657) and the Major Program for Creative Research Groups of Guizhou Provincial Education Department (No. 2017-028).

A novel supramolecular host-guest complex of the anticancer drug capecitabine (CAP) with symmetrical α, α',δ, δ'-tetramethyl-cucurbit[6]uril (TMeQ[6]) has been characterized using nuclear magnetic resonance spectroscopy, MALDI-TOF mass spectrometry, isothermal titration calorimetryand fluorescence spectroscopy analyses. The result revealed that the alkyl chain of CAP is located inside the cavities of TMeQ[6], whereas the other part of CAP remains outside the portal. Our results suggest that TMeQ[6] could be a promising candidate for use as an excipient in the pharmaceutical and medical research ?elds.

Key words: supramolecular, host-guest, cucurbit[n]uril, capecitabine, self-assembly