Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 1823-1834.DOI: 10.6023/cjoc202003066 Previous Articles     Next Articles


田雪琪, 左旻瓒, 牛蓬勃, 王开亚, 胡晓玉   

  1. 南京航空航天大学材料与科学技术学院 南京 211106
  • 收稿日期:2020-03-30 修回日期:2020-04-21 发布日期:2020-05-08
  • 通讯作者: 胡晓玉
  • 基金资助:

Research Advances of Host-Guest Supramolecular Self-Assemblies with Aggregration-Induced Emission Effect and Their Applications in Biomedical Field

Tian Xueqi, Zuo Minzan, Niu Pengbo, Wang Kaiya, Hu Xiaoyu   

  1. College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106
  • Received:2020-03-30 Revised:2020-04-21 Published:2020-05-08
  • Supported by:
    Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20180055), the Fundamental Research Funds for the Central Universities (No. NE2019002) and the China Postdoctoral Science Foundation Project (No. 2019M661816).

Host-guest interaction, as one of the most important behaviors in supramolecular self-assemblies, is often used to construct functional supramolecular materials. Based on host-guest interaction, it has become a hotspot in supramolecular chemistry by utilizing macrocyclic hosts and guests with aggregation-induced emission (AIE) properties as building blocks to construct supramolecular system, which can be widely used in drug delivery, cellular imaging, biosensing and so on. According to the origination of fluorescence effects of supramolecular assemblies, either from the host or guest molecules, the recent 5-year advances of AIE supramolecular self-assemblies based on host-guest interaction by utilizing macrocycles such as cyclodextrin, calixarene, cucurbituril, pillararene and other water-soluble host molecules are summarized, and their applications in the biomedical field are discussed.

Key words: host-guest interaction, self-assembly, aggregation-induced emission, cell imaging, drug delivery