Ruthenium-Catalyzed C(sp2)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group

doi:10.6023/cjoc201901005

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (6): 1735-1742.DOI: 10.6023/cjoc201901005 Previous Articles Next Articles

Special Issue: 金属有机化学；碳氢活化合辑2018-2019

Articles

钌催化下吡唑基导向的1-苄基-1H-吡唑的C(sp²)-H键烯基化和烷基化反应

徐文韬, 王宁, 张梦烨, 史达清

苏州大学材料与化学化工学部苏州 215123

收稿日期:2019-01-05 修回日期:2019-02-27 发布日期:2019-03-21
通讯作者: 史达清 E-mail:dqshi@suda.edu.cn
基金资助:
江苏省高校自然科学重大研究（No.15KJA150006）资助项目.

Ruthenium-Catalyzed C(sp²)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group

Xu Wentao, Wang Ning, Zhang Mengye, Shi Daqing

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Received:2019-01-05 Revised:2019-02-27 Published:2019-03-21
Contact: 10.6023/cjoc201901005 E-mail:dqshi@suda.edu.cn
Supported by:
Project supported by the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006).

1. Ruthenium-Catalyzed C(sp²)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group.PDF(1937KB)

Abstract

A practical ruthenium-catalyzed C(sp²)-H alkenylation and alkylation of 1-benzyl-1H-pyrazole with alkene or a,β-unsaturated ketones under the assistance of pyrazole group were developed. This method has the advantages of high selectivity, providing only the ortho-alkenylation or ortho-alkylation products in high yields. This protocol provides an efficient and new method for the functionalization of 1-benzyl-1H-pyrazoles.

Key words: 1-benzyl-1H-pyrazole, alkenylation, alkylation, C(sp²)-H bond

Cite this article

Xu Wentao, Wang Ning, Zhang Mengye, Shi Daqing. Ruthenium-Catalyzed C(sp²)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group[J]. Chin. J. Org. Chem., 2019, 39(6): 1735-1742.

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钌催化下吡唑基导向的1-苄基-1H-吡唑的C(sp²)-H键烯基化和烷基化反应

Ruthenium-Catalyzed C(sp²)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group

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钌催化下吡唑基导向的1-苄基-1H-吡唑的C(sp2)-H键烯基化和烷基化反应