Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (11): 3686-3696.DOI: 10.6023/cjoc202006008 Previous Articles     Next Articles

Special Issue: 创刊四十周年专辑


孙强盛, 孙伟   

  1. 中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室 分子合成科学卓越创新中心 兰州 730000
  • 收稿日期:2020-06-05 修回日期:2020-06-19 发布日期:2020-07-09
  • 通讯作者: 孙伟
  • 基金资助:

Recent Progress in C(sp3)-H Asymmetric Oxidation Catalyzed by Bioinspired Metal Complexes

Sun Qiangsheng, Sun Wei   

  1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000
  • Received:2020-06-05 Revised:2020-06-19 Published:2020-07-09
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21773273, 21473226, 21902166), the Key Research Program of Frontier Sciences, CAS (No. QYZDJ-SSW-SLH051) and the Natural Science Foundation of Jiangsu Province (No. BK20170420).

C—H oxidation represents one of the most important reactions in organic chemistry. In particular, asymmetric C—H oxidation, which can directly convert simple alkanes into chiral alcohols, ketones, aldehydes and so on, provides more economic and efficient access to the synthesis of complex molecules. Although increasing efforts have been devoted to this area, asymmetric C—H oxidation is still far away from the goal due to the inert nature of C—H and the subtle stereo-difference of C—H bonds. The factors that dictate the selectivity of asymmetric C—H oxidation, mechanism of the C—H oxidation catalyzed by enzyme and some successful examples achieved by biomimetic metal complexes bearing various ligands are reviewed.

Key words: C-H oxidation, metal complex, asymmetric oxidation