Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2705-2712.DOI: 10.6023/cjoc201904014 Previous Articles     Next Articles



刘颖杰a*(), 林立青a, 韩莹徽a, 张鑫b   

  1. a 哈尔滨商业大学药学院 哈尔滨 150076
    b 哈尔滨医科大学附属第一医院泌尿外科 哈尔滨 150001
  • 收稿日期:2019-04-06 修回日期:2019-05-27 发布日期:2019-06-12
  • 通讯作者: 刘颖杰
  • 基金资助:

Recent Advances of the Synthesis of Indolines by Unactivated Alkenes

Liu Yingjiea*(), Lin Liqinga, Han Yinghuia, Zhang Xinb   

  1. a School of Pharmacy, Harbin University of Commerce, Harbin 150076
    b Department of Urology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001
  • Received:2019-04-06 Revised:2019-05-27 Published:2019-06-12
  • Contact: Liu Yingjie
  • Supported by:
    Project supported by the Program of Young Innovators of Education Department of Heilongjiang Province(UNPYSCT-2016181)

Indolines, an important class of heterocycles with a wide range of biological properties, are a key structural motif in numerous natural products and biologically active compounds. As a result, efficient methods for indolines synthesis have been the subject of extensive studies. In this review, recent studies on the synthesis of various functionalized indolines using unactivated alkenes are described. It involves radical addition/cyclization reaction in the presence of oxidizing agent, which is usually carried out under neutral reaction conditions using readily available oxidizing agents and different transition metals or under metal-free as catalysts.

Key words: indolines, alkenes, oxidizing agent, functional group, free radical