Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3289-3299.DOI: 10.6023/cjoc202003014 Previous Articles     Next Articles

Special Issue: 黄乃正院士七十华诞专辑

天然产物Gracilioethers和Hippolachnin A的合成研究进展

吴璟华, 王诚, 陈鹏全, 马志强   

  1. 华南理工大学化学与化工学院 广东省功能分子工程重点实验室 广州 510641
  • 收稿日期:2020-03-06 修回日期:2020-04-08 发布日期:2020-04-17
  • 通讯作者: 马志强
  • 基金资助:

Synthetic Progress of Natural Products Gracilioethers and Hippolachnin A

Wu Jinghua, Wang Cheng, Chen Pengquan, Ma Zhiqiang   

  1. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641
  • Received:2020-03-06 Revised:2020-04-08 Published:2020-04-17
  • Supported by:
    Project supported by the National Program on Key Research Project (No. 2016YFA0602900), the Science and Technology Program of Guangzhou City (No. 201707010073) and the National Natural Science Foundation of China (Nos. 21672073, 21871098).

Gracilioethers and hippolachnin A were isolated from marine sponge. Gracilioethers showed antimalarial activity while hippolachnin A exhibited strong antifungal activity. Their fascinating structures and outstanding biological activities have attracted attentions from chemists. Progress on the synthesis of gracilioethers with tricyclic skeleton and hippolachnin A are reviewed in terms of the key strategies employed.

Key words: gracilioether, hippolachnin A, natural product, total synthesis