Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (9): 2755-2763.DOI: 10.6023/cjoc202003068 Previous Articles     Next Articles


刘子琳, 张小洁, 张恒, 姜辉, 赵雪梅, 石林林, 朱新举, 郝新奇, 宋毛平   

  1. 郑州大学化学学院 郑州 450001
  • 收稿日期:2020-03-31 修回日期:2020-05-27 发布日期:2020-06-13
  • 通讯作者: 赵雪梅, 石林林;
  • 基金资助:

Phathalocyanine Metal Complexes (M=Fe, Co, and Cu) Catalyzed Aerobic Oxidation of 2-Amino-benzyl Alcohols to Access Quinazolines and Quinolines

Liu Zilin, Zhang Xiaojie, Zhang Heng, Jiang Hui, Zhao Xuemei, Shi Linlin, Zhu Xinju, Hao Xinqi, Song Maoping   

  1. College of Chemistry, Zhengzhou University, Zhengzhou 450001
  • Received:2020-03-31 Revised:2020-05-27 Published:2020-06-13
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21672192, 21803059, U1904212, 21929101).

Phathalocyanine metal complexes catalyzed oxidative condensation of 2-aminobenzyl alcohols with nitriles and ketones has been developed under air to afford quinazolines and quinolines, respectively. After systematic investigation, iron(II) phathalocyanine displayed higher catalytic activity in quinazoline synthesis and copper(II) phathalocyanine showed higher efficiency in quinoline preparation. Under the optimized conditions, various nitriles and ketones were well adaptted to give the corresponding products in good yields.

Key words: phathalocyanine metal complexes, quinazolines, quinolines, aerobic oxidation