Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (1): 274-284.DOI: 10.6023/cjoc202204068 Previous Articles     Next Articles



陈艺方, 罗鑫, 王余, 邢志富, 彭菊, 陈吉祥*()   

  1. 贵州大学精细化工研究开发中心 绿色农药与农业生物工程国家重点实验室培育基地 教育部绿色农药与农业生物工程重点实验室 贵阳 550025
  • 收稿日期:2022-04-28 修回日期:2022-07-19 发布日期:2022-08-17
  • 通讯作者: 陈吉祥
  • 基金资助:
    国家重点研发计划(2021YFD1400800); 贵州省自然科学基金(QKHJC-ZK[2022]039); 贵州大学自然科学基金((2021)01)

Design, Synthesis and Antibacterial Activity of 1,3,4-Oxadiazole Sufones Containing Sulfonamide Structure

Yifang Chen, Xin Luo, Yu Wang, Zhifu Xing, Ju Peng, Jixiang Chen()   

  1. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025
  • Received:2022-04-28 Revised:2022-07-19 Published:2022-08-17
  • Contact: Jixiang Chen
  • Supported by:
    National Key Research and Development Program of China(2021YFD1400800); Natural Science Foundation of Guizhou Province(QKHJC-ZK[2022]039); Natural Science Foundation of Guizhou University((2021)01)

To discover new antibacterial agents, twenty-three 1,3,4-oxadiazolsulfone compounds containing a sulfonamide structure were designed and synthesized by active substructure splicing, and their antibacterial activities were tested. Most of the compounds exhibited excellent in vitro antibacterial activity against Xanthomonas oryzae pv. oryzicola (Xoc) and Xanthomonas oryzae pv. oryzae (Xoo) at a concentration of 100 µg/mL. Except for N-((5-(propylsulfonyl)-1,3,4-oxadiazo- 2-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide (18), the median effective concentration (EC50) values of other compounds against Xoc were 1.3~22.5 µg/mL, and the EC50 of all compounds against Xoo were 1.1~32.7 µg/mL, which were better than the control agents bismerthiazol (84.1 and 71.4 µg/mL) and thiodiazole copper (122.1 and 84.0 µg/mL). In addition, 4-fluoro-N-((5-(methylsulfonyl)-1,3,4-oxadiazole-2-yl)methyl)benzenesulfonamide (4) can inhibit the growth of Xoc and Xoo by inhibiting the production of exopolysaccharide (EPS) and the formation of biofilm, changing the permeability of cell membrane and cell surface morphology.

Key words: sulfonamide, 1,3,4-oxadiazole, synthesis, antibacterial activity, physiology and biochemistry