Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (11): 3588-3605.DOI: 10.6023/cjoc202203016 Previous Articles     Next Articles

REVIEWS

槲皮素衍生物的合成研究进展

毛雅君, 邵香敏, 李阳杰, 曹瑞梅, 冯亚莉, 翟广玉*()   

  1. 郑州工业应用技术学院 药学与化学工程学院 郑州 450041
  • 收稿日期:2022-03-06 修回日期:2022-04-16 发布日期:2022-07-05
  • 通讯作者: 翟广玉
  • 基金资助:
    郑州市高等学校名师技术技能工作室([2015]70)

Research Progress on the Synthesis of Quercetin Derivatives

Yajun Mao, Xiangmin Shao, Yangjie Li, Ruimei Cao, Yali Feng, Guangyu Zhai()   

  1. School of Pharmacy and Chemical Engineering, Zhengzhou Institute of Technology, Zhengzhou 450041
  • Received:2022-03-06 Revised:2022-04-16 Published:2022-07-05
  • Contact: Guangyu Zhai
  • Supported by:
    Technical Skills Studio of Famous Teachers in Zhengzhou Colleges and Universities([2015]70)

Quercetin, as a natural antioxidant, is mainly found in vegetables, fruits and other plants. It can regulate many intracellular and extracellular signaling pathways related to disease progression. It can be anti-inflammatory, antiviral, anticancer, prevention and treatment of cardiovascular and cerebrovascular diseases, thus has a wide range of pharmacological activities. Due to the structural characteristics of quercetin, its low bioavailability limits its clinical application. However, the low molecular mass and easily modifiable chemical groups of quercetin make it attractive for drug development. Therefore, researchers have designed and synthesized new quercetin derivatives through various methods to improve its unfavorable factors. Many quercetin derivatives with excellent properties, good solubility, high bioavailability, stable metabolism, low toxicity and significant biological activity have been synthesized. The recent progress in the synthesis of quercetin derivatives and their biological activities is reviewed, providing a reference for the further development of quercetin derivatives.

Key words: quercetin, derivative, synthesis, antioxidant, anticancer, biological activity