Research Progress on the Construction and Application of Macrocyclic Fluorescent Sensing Platform Based on Indicator Displacement Assay

doi:10.6023/cjoc202310017

Abstract

Supramolecular fluorescent sensors can address various detection and bioimaging issues related to the environment and human health. Indicator displacement assay (IDA) is a supramolecular fluorescence sensing method that can convert the chemical changes caused by molecular recognition into easily observed fluorescence signals. It provides a unique and innovative sensing method for the detection of analytes. In recent years, IDA based on non-covalent binding has been developed rapidly due to its advantages of high sensitivity, adjustability, real-time, and low synthesis effort. In order to meet the diverse needs of IDA development, a variety of supramolecular macrocyclic hosts have been involved in the construction of IDA sensors, such as calix[n]arenes, cucurbit[n]uril, pillar[n]arenes, etc. The recent research progress in this field based on different classes of macrocycles is briefly reviewed, focusing on the application in biochemical sensing, and providing a reference for the construction and application of novel fluorescent biochemical sensing platforms based on IDA in the future.

Key words: indicator displacement assay, supramolecular chemistry, host-guest interaction, macrocyclic host

Cite this article

Zeya Shen, Shiyao Li, Liupan Yang, Lili Wang, Huan Yao. Research Progress on the Construction and Application of Macrocyclic Fluorescent Sensing Platform Based on Indicator Displacement Assay[J]. Chinese Journal of Organic Chemistry, 2024, 44(4): 1151-1159.

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Fig. & Tab. 11

Figure 1. Fluorescent sensing for citrate based on atripodal anion host-fluorophore complex[1]

Figure 2. Schematic illustration of monitoring the uptake and transport of organic analytes in living cells by using IDA[20]

Figure 3. Strategies for creating hypoxia-responsive systems[30]

Figure 4. Schematic illustration of the binding between LPA and GC5A and the IDA principle of fluorescence sensing[21]

Figure 5. Schematic illustration for IDA operating principle of TMAO fluorescence sensing by the GC5A·Fl reporter pair and chemical structures of the tested reporter pairs[22]

Figure 6. FRET assisted IDA supramolecular bioimaging strategies[25]

Figure 7. Product versus substrate-selective tandem assays for monitoring enzymatic activity[36]

Figure 8. Strategy for supramolecular membrane transport assays to detect peptide transport[40]

Figure 9. Schematic representation of the unimolecular CB[n]- based chemosensor[41]

Figure 10. Schematic iSchematic illustration of the sequential host-guest and second-stage ordered self-assembly between probes P1~P3 and DCM7-β-CD[52]

Figure 11. Schematic illustration of the tetralactam macrocycle based dual-mode colorimetric and fluorescence indicator displacement assay for UA[54]

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