Recent progress on Methods for the preparation of mono/di/trifluoromethoxylation reagents

doi:10.6023/cjoc202403011

Abstract

Fluorinated organic molecules are widely used in the fields of pharmaceuticals, agricultural chemistry, and materials science. In the pharmaceutical industry, the introduction of fluorinated methoxy groups can enhance the bioavailability and metabolic stability of drugs, thereby improving their efficacy. In addition, fluoromethoxy groups can also regulate the stereochemistry and electronic structure of molecules in drug design, further improving the activity and selectivity of drugs. In the field of agriculture, the insecticidal and bactericidal properties of organic fluorine compounds have been widely applied. In the field of materials science, fluorinated methoxy compounds have special electrochemical properties and thermal stability, making them widely used in the synthesis and modification of materials such as batteries, coatings, catalysts, etc. Therefore, how to easily and efficiently introduce fluorinated methoxy groups into molecules has become a research hotspot in the field of organic fluorine chemistry.

Key words: monofluoromethoxy reagent, difluoromethoxy reagent, trifluoromethoxy reagent, preparation

Cite this article

Wei Zheng, Fengxue Liu, Hongqiong Zhao, Ying Xu, Ning Chen, Yingjie Liu. Recent progress on Methods for the preparation of mono/di/trifluoromethoxylation reagents[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202403011.

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