Progress in functional group reaction of N-α-Csp3-H bond catalyzed by transition metals

doi:10.6023/cjoc202404040

Abstract

Functionalization of C-H bonds is a very important research area in organic synthetic chemistry. In many C-H bonds located in different chemical environments, the induced effect of the nitrogen atom at the N-α C_sp3-H position makes the α C_sp3-H bond more active compared to other C_sp3-H bonds, and the regioselective functionalization of the α C_sp3-H bond is also better achieved with the help of the nitrogen atom. Therefore, the functionalization of the α C_sp3-H bond of nitrogen atoms is a very practical synthetic strategy, this provides more possibilities for the synthesis and development of organic compounds containing nitrogen atoms (such as nicotinamide and quinine). This article reviews the current development of functionalization of the α C_sp3-H bond of nitrogen atoms in the past twenty years and looks forward to the potential of this method in the future.

Key words: Nitrogen atom, functional group, C_sp3-H, transition metal

Cite this article

Zhang Tengfei, Chang Zhe, Chen Chunxia, Peng Jinsong. Progress in functional group reaction of N-α-C_sp3-H bond catalyzed by transition metals[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202404040.

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过渡金属催化氮原子α位C_sp3-H键官能团化反应研究进展