Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (3): 892-902.DOI: 10.6023/cjoc202309024 Previous Articles     Next Articles

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电化学促进未活化C(sp3)—H官能团化研究进展

高瑞林, 文丽荣, 郭维斯*()   

  1. 青岛科技大学化学与分子工程学院 山东青岛 266042
  • 收稿日期:2023-09-22 修回日期:2023-11-21 发布日期:2024-04-02
  • 基金资助:
    山东省自然科学基金(ZR2020MB005)

Recent Advances in Electrochemical-Promoted Unactivated C(sp3)—H Functionalization

Ruilin Gao, Lirong Wen, Weisi Guo()   

  1. College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology, Qingdao, Shandong 266042
  • Received:2023-09-22 Revised:2023-11-21 Published:2024-04-02
  • Contact: *E-mail: wsguo@qust.edu.cn
  • Supported by:
    Natural Science Foundation of Shandong Province(ZR2020MB005)

Organic electrosynthesis replaces traditional chemical oxidants or reductants with traceless electrons, which has the advantages of sustainability and easy to scale up. The functionalization of unactivated C(sp3)—H bond can directly introduce the target functional group into the molecules, avoiding pre-functionalization and possessing both atomic and step economies. With the development of organic electrosynthesis, electrochemical-promoted functionalization of unactivated C(sp3)—H bond has become one of the hotspots in organic synthesis. The functional groups are classified according to the types of functional groups, and the recent achievements related to the functionalization of unactivated C(sp3)—H bond are summarized, with emphasis on analyzing reaction advantages, substrate scope, and reaction mechanism. Finally, the current challenges and future development are briefly discussed.

Key words: organic electrosynthesis, unactivated C(sp3)—H bond, functionalization