Total syntheses of Cochlearol F and Didehydroconicol were accomplished through the Suzuki coupling reaction, with the innovative use of biphenylboronic acid. In the total synthesis of Cochlearol F, the key reaction involved the coupling of biphenylboronic acid with enol trifluoromethanesulfonate to construct a new carbon-carbon bond, requiring four steps in total, with an overall yield of 25%. In the total synthesis of Didehydroconicol, the key reaction was the insertion of carbon monoxide into biphenylboronic acid to form a biphenyl lactone, requiring seven steps in total, with an overall yield of 23%. This synthetic strategy will provide a reference for the synthesis of natural products containing biphenyl unit.

Key words: Total synthesis, Suzuki cross-coupling, Cochlearol F, Didehydroconicolord