Efficient Oxidation of Alcohols Using a Bioinspired Tetradentate Aminopyridine Manganese Catalyst with H2O2: Batch and Continuous Flow Studies

doi:10.6023/cjoc202508025

仿生四齿胺基吡啶锰催化剂/H₂O₂的醇类化合物高效氧化：间歇和连续流研究

夏春年^*,a, 陈凯林^a, 金诺琪^a, 南欣卉^a, 汪兵洋^*,b, 吴馨怡^a, 孙强盛^b, 孙伟^*,b

^a浙江工业大学药学院杭州 310014;
^b中国科学院兰州化学物理研究所低碳催化与二氧化碳利用国家重点实验室兰州 730000

收稿日期:2025-08-28 修回日期:2025-11-01
基金资助:
国家自然科学基金(No. 22361142751, 22372183, 22302213)、甘肃省重大科技专项(No. 22ZD6GA003)、中国科学院兰州化学物理研究所重点培育项目(No. ZYFZFX-9)

Efficient Oxidation of Alcohols Using a Bioinspired Tetradentate Aminopyridine Manganese Catalyst with H₂O₂: Batch and Continuous Flow Studies

Xia Chunnian^*,a, Chen Kailin^a, Jin, Nuoqi^a, Nan Xinghui^a, Wang Bingyang^*,b, Wu Xinyi^a, Sun Qiangsheng^b, Sun Wei^*,b

^aCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014;
^bState Key Laboratory for Low Carbon Catalysis and CO₂ Utilization, Lanzhou Institute of Chemical Physics, Lanzhou 730000

Received:2025-08-28 Revised:2025-11-01
Contact: ^*E-mail: xcn77@zjut.edu.cn, wangbingyang@licp.cas.cn, wsun@licp.cas.cn
Supported by:
National Natural Science Foundation of China (No. 22361142751, 22372183, 22302213), the Major Project of Gansu Province, China (No. 22ZD6GA003), and the Major Program of the Lanzhou Institute of Chemical Physics, CAS (No. ZYFZFX-9).

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Abstract

Bioinspired manganese complexes with tetradentate aminopyridine ligands (N4) have shown excellent promise as effective catalysts for various selective oxidation reactions. In this study, we report the synthesis of a series of Mn-N4 and their application in the catalytic oxidation of secondary alcohols. This method utilizes hydrogen peroxide as an environmentally benign oxidant, with a small amount of acetic acid as an additive. Notably, the continuous-flow process using this catalyst system achieves rapid conversion, reducing the reaction time from 90 min in a traditional batch system to 1.6 min residence time in the continuous-flow process. This approach offers a promising and practical strategy for the industrial oxidation of secondary alcohols, demonstrating significant potential for broader applications.

Key words: bioinspired catalysis, oxidation of alcohols, manganese complexes, continuous flow

Cite this article

Xia Chunnian, Chen Kailin, Jin, Nuoqi, Nan Xinghui, Wang Bingyang, Wu Xinyi, Sun Qiangsheng, Sun Wei. Efficient Oxidation of Alcohols Using a Bioinspired Tetradentate Aminopyridine Manganese Catalyst with H₂O₂: Batch and Continuous Flow Studies[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202508025.

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仿生四齿胺基吡啶锰催化剂/H₂O₂的醇类化合物高效氧化：间歇和连续流研究

Efficient Oxidation of Alcohols Using a Bioinspired Tetradentate Aminopyridine Manganese Catalyst with H₂O₂: Batch and Continuous Flow Studies

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仿生四齿胺基吡啶锰催化剂/H2O2的醇类化合物高效氧化：间歇和连续流研究