Rapid and controlled reduction of acyl chlorides to aldehydes using pinacolborane

doi:10.6023/cjoc202509007

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频哪醇硼烷快速可控还原酰氯合成醛

刘辉杨^a,c, 陈都^a, 苏毅进^a,*, 张鹏^a,*, 刘超^b,*

^a中国科学院兰州化学物理研究所,低碳催化与二氧化碳利用全国重点实验室甘肃 730000;
^b南京大学化学化工学院,绿色化学与工程研究院,配位化学全国重点实验室江苏 215163;
^c中国科学院大学北京 100049

收稿日期:2025-09-05 修回日期:2025-10-07
通讯作者: *E-mail: suyj@licp.cas.cn; pengzhang@licp.cas.cn; chao.liu@nju.edu.cn

Rapid and controlled reduction of acyl chlorides to aldehydes using pinacolborane

Liu Huiyang^a,c, Chen Du^a, Su Yijin^a,*, Zhang Peng^a,*, Liu Chao^b,*

^aState Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China;
^bState Key Laboratory of Coordination Chemistry, Institute of Green Chemistry and Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Suzhou, Jiangsu 215163, China;
^cUniversity of Chinese Academy of Sciences, Beijing 100049, China

Received:2025-09-05 Revised:2025-10-07

In this study, we developed a method for the rapid reduction of acyl chlorides to aldehydes using pinacolborane (HBpin) as the reducing agent. The method exhibits excellent generality for both aromatic and aliphatic substrates, affording aldehydes in isolated yields of up to 88% with broad functional group tolerance, including cyano, halogen, alkenyl, ketone, and ester groups. Moreover, the method enables gram-scale aldehyde synthesis and shows high efficiency in reducing in situ generated acyl chlorides, thereby enhancing its synthetic practicality.

Key words: Pinacolborane, reduction, acyl chlorides, aldehydes

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Liu Huiyang, Chen Du, Su Yijin, Zhang Peng, Liu Chao. Rapid and controlled reduction of acyl chlorides to aldehydes using pinacolborane[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202509007.

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频哪醇硼烷快速可控还原酰氯合成醛

Rapid and controlled reduction of acyl chlorides to aldehydes using pinacolborane

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